| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Endo Ayaka (日) (読)
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| 2. | (英) Kohsaka Shun (日) (読)
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| 3. | (英) Suzuki Shinya (日) (読)
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| 4. | (英) Atarashi Hirotsugu (日) (読)
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| 5. | (英) Kamakura Shiro (日) (読)
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| 6. | (英) Sakurai Masayuki (日) (読)
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| 7. | (英) Nakaya Haruaki (日) (読)
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| 8. | (英) Fukatani Masahiko (日) (読)
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| 9. | (英) Mitamura Hideo (日) (読)
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| 10. | (英) Yamazaki Tsutomu (日) (読)
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| 11. | (英) Yamashita Takeshi (日) (読)
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| 12. | (英) Ogawa Satoshi (日) (読)
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| 13. | (英) .J-RHYTHM Investigators (日) (読)
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| ○題名 (必須): | □ | (英) Impact of drug alteration to maintain rhythm control in paroxysmal atrial fibrillation. Subanalysis from J-RHYTHM study. (日)
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| ○要約 (任意): | □ | (英) BACKGROUND: The Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM) study showed rhythm control was associated with fewer changes in the assigned treatment strategy compared to rate control in atrial fibrillation (AF). The aim was to describe how antiarrhythmics (AAs) were altered in the rhythm control arm and whether altering AAs would impact long-term outcomes.METHODS AND RESULTS: Of 390 enrolled patients, 23.5% altered their AAs (drug alteration [DA] group). The hard endpoint (HE) was defined as a composite of death, stroke, embolism, major bleeding or heart failure hospitalization; soft endpoint (SE) was defined physical/psychological disability requiring alteration of treatment strategy. The patients were followed for 1.7 years. No significant difference was noted in the occurrence of HE (4.0% vs 6.5%, P=0.31), but DA-group patients had higher rates of SE (9.3% vs 18.4%, P=0.017) compared to single AA patients. The DA group was also associated with the occurrence of SE after adjustment (HR 1.90, P=0.042). When the DA group was subdivided according to the use of class III drugs or change of drugs between classes, there were no differences in outcomes.CONCLUSIONS: The need to change AA was associated with physical/psychological disabilities that seemed not to be relieved simply by changing AAs, and this should be considered as a marker for refractory paroxysmal AF requiring other strategies. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | 社団法人 日本循環器学会
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| ○誌名 (必須): | □ | Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
| ○ISSN (任意): | □ | 1347-4820
ISSN: 1346-9843
(pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation SocietyTitle(ISO): Circ JSupplier: 社団法人日本循環器学会Publisher: Japanese Circulation Society (NLM Catalog)
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| ○巻 (必須): | □ | 74
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 870 875
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 4月 3日 (平成 22年 4月 3日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1253/circj.CJ-09-0643 (→Scopusで検索)
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| ○PMID (任意): | □ | 20379004 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-77951708270
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