『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=287884EID:287884, Map:0, LastModified:2014年12月17日(水) 16:00:27, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 裕彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔組織学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.岡村 裕彦
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2.楊 諦
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3.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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4.寺町 順平
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5.羽地 達次
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題名 (必須): (英) Reduction of PP2A C stimulates adipogenesis by regulating the Wnt/GSK-3/-catenin pathway and PPAR expression  (日)    [継承]
副題 (任意):
要約 (任意): (英) Serine/threonine protein phosphatase 2A (PP2A) regulates several physiological processes such as the cell cycle, cell growth, apoptosis, and signal transduction. In this study, we examined the expression and role of PP2A Cα in adipocyte differentiation. PP2A Cα expression and PP2A activity decreased during adipocyte differentiation in C3H10T1/2 and 3T3-L1 cells and the expression of adipocyte marker genes such as PPARγ and adiponectin increased. To further clarify the role of PP2A Cα in adipocyte differentiation, we constructed PP2A knockdown cells by infecting C3H10T1/2 cells with a lentivirus expressing a shRNA specific for the PP2A Cα (shPP2A cells). Silencing of PP2A Cα in C3H10T1/2 cells dramatically stimulated adipocyte differentiation and lipid accumulation, which were accompanied by expression of adipocyte marker genes. Silencing of PP2A Cα suppressed Wnt10b expression and reduced the levels of the inactivated form of GSK-3β (phospho-GSK-3β), leading to the reduction of β-catenin levels in the nucleus and its transcriptional activity. Treatment with LiCl, a GSK-3β inhibitor, and inhibition of PPARγ expression suppressed the accelerated adipogenesis of shPP2A cells. Our data indicate that PP2A Cα plays an important role in the regulation of adipocyte differentiation by regulating the Wnt/GSK-3β/β-catenin pathway and PPARγ expression.  (日)    [継承]
キーワード (推奨): 1.PP2A (PP2A) [継承]
2.プロテインフォスファターゼ (protein phosphatase) [継承]
3.脂肪細胞 (adipocyte) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ([Elsevier Science])
(pISSN: 0167-4889)

ISSN (任意): 0167-4889
ISSN: 0167-4889 (pISSN: 0167-4889, eISSN: 1879-2596)
Title: Biochimica et biophysica acta. Molecular cell research
Title(ISO): Biochim Biophys Acta Mol Cell Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1843 [継承]
(必須): 11 [継承]
(必須): 2376 2384 [継承]
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年月日 (必須): 西暦 2014年 6月 17日 (平成 26年 6月 17日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbamcr.2014.06.008    (→Scopusで検索) [継承]
PMID (任意): 24949891    (→Scopusで検索) [継承]
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WOS (任意): 000342527800002 [継承]
Scopus (任意): 2-s2.0-84905178655 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.bbamcr.2014.06.008  (日)    [継承]
2.(英) Article.ELocationID: S0167-4889(14)00211-0  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Adipogenesis  (日)    [継承]
5.(英) KeywordList.Keyword: PPARγ  (日)    [継承]
6.(英) KeywordList.Keyword: Protein phosphatase 2A  (日)    [継承]
7.(英) KeywordList.Keyword: Wnt/GSK-3β/β-catenin  (日)    [継承]

標準的な表示

和文冊子 ● Hirohiko Okamura, Di Yang, Kaya Yoshida, Jumpei Teramachi and Tatsuji Haneji : Reduction of PP2A C stimulates adipogenesis by regulating the Wnt/GSK-3/-catenin pathway and PPAR expression, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1843, No.11, 2376-2384, 2014.
欧文冊子 ● Hirohiko Okamura, Di Yang, Kaya Yoshida, Jumpei Teramachi and Tatsuji Haneji : Reduction of PP2A C stimulates adipogenesis by regulating the Wnt/GSK-3/-catenin pathway and PPAR expression, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1843, No.11, 2376-2384, 2014.

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