『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=287580)

EID=287580EID:287580, Map:0, LastModified:2015年9月12日(土) 20:07:29, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[茂谷 康], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hasegawa, M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Imamura, R (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.茂谷 康 ([徳島大学.先端酵素学研究所.基幹研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Nishiuchi, T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Matsumoto, N (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Kinoshita, T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Suda, T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Mechanism and repertoire of ASC-mediated gene expression  (日)    [継承]
副題 (任意):
要約 (任意): (英) Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor molecule that mediates inflammatory and apoptotic signals. Although the role of ASC in caspase-1-mediated IL-1beta and IL-18 maturation is well known, ASC also induces NF-kappaB activation and cytokine gene expression in human cells. In this study, we investigated the molecular mechanism and repertoire of ASC-induced gene expression in human cells. We found that the specific activation of ASC induced AP-1 activity, which was required for optimal IL8 promoter activity. ASC activation also induced STAT3-, but not STAT1-, IFN-stimulated gene factor 3- or NF-AT-dependent reporter gene expression. The ASC-mediated AP-1 activation was NF-kappaB-independent and primarily cell-autonomous response, whereas the STAT3 activation required NF-kappaB activation and was mediated by a factor that can act in a paracrine manner. ASC-mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8-targeting small-interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas-associated death domain protein (FADD) dominant-negative mutants, FADD- or RICK-targeting small-interfering RNAs, or a MEK inhibitor, indicating that the ASC-induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK. DNA microarray analyses identified 75 genes that were induced by ASC activation. A large proportion of them was related to transcription (23%), inflammation (21%), or cell death (16%), indicating that ASC is a potent inducer of inflammatory and cell death-related genes. This is the first report of ASC-mediated AP-1 activation and the repertoire of genes induced downstream of ASC activation.  (日)    [継承]
キーワード (推奨): 1. (英) Caspase 8 (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Cytoskeletal Proteins (日) (読) [継承]
4. (英) Gene Expression Profiling (日) (読) [継承]
5. (英) Gene Expression Regulation (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Interleukin-8 (日) (読) [継承]
8. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
9. (英) Promoter Regions, Genetic (日) (読) [継承]
10. (英) STAT3 Transcription Factor (日) (読) [継承]
11. (英) Transcription Factor AP-1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 182 [継承]
(必須): 12 [継承]
(必須): 7655 7662 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 6月 15日 (平成 21年 6月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0800448    (→Scopusで検索) [継承]
PMID (任意): 19494289    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.4049/jimmunol.0800448  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● M Hasegawa, R Imamura, Kou Motani, T Nishiuchi, N Matsumoto, T Kinoshita and T Suda : Mechanism and repertoire of ASC-mediated gene expression, The Journal of Immunology, Vol.182, No.12, 7655-7662, 2009.
欧文冊子 ● M Hasegawa, R Imamura, Kou Motani, T Nishiuchi, N Matsumoto, T Kinoshita and T Suda : Mechanism and repertoire of ASC-mediated gene expression, The Journal of Immunology, Vol.182, No.12, 7655-7662, 2009.

関連情報

Number of session users = 0, LA = 0.22, Max(EID) = 383285, Max(EOID) = 1024421.