| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Soejima Hirofumi (日) (読)
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| 2. | (英) Ogawa Hisao (日) (読)
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| 3. | (英) Morimoto Takeshi (日) (読)
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| 4. | (英) Nakayama Masafumi (日) (読)
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| 5. | (英) Okada Sadanori (日) (読)
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| 6. | (英) Uemura Shiro (日) (読)
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| 7. | (英) Kanauchi Masao (日) (読)
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| 8. | (英) Doi Naofumi (日) (読)
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| 9. | (英) Sakuma Mio (日) (読)
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| 10. | (英) Jinnouchi Hideaki (日) (読)
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| 11. | (英) Sugiyama Seigo (日) (読)
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| 12. | (英) Waki Masako (日) (読)
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| 13. | (英) Saito Yoshihiko (日) (読)
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| 14. | (英) .the JPAD trial investigators (日) (読)
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| ○題名 (必須): | □ | (英) Aspirin reduces cerebrovascular events in type 2 diabetic patients with poorly controlled blood pressure. Subanalysis from the JPAD trial. (日)
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| ○要約 (任意): | □ | (英) BACKGROUND: There are few data that demonstrate a significant effect of aspirin therapy for diabetic patients. To clarify the effect of the primary prevention of aspirin therapy in diabetic patients, the relationship between blood pressure (BP) and the incidence of atherosclerotic events was investigated in participants in the Japanese primary prevention of atherosclerosis with aspirin for diabetes (JPAD) trial.METHODS AND RESULTS: We divided the JPAD participants according to their systolic (SBP) and diastolic (DBP) BPs at enrollment (SBP 140 mmHg and/or DBP 90 mmHg: unattained group, SBP <140 mmHg and DBP <90 mmHg: attained group). The incidence of the primary atherosclerotic events, especially cerebrovascular events, was higher in the unattained group than in the attained group. The incidence of cerebrovascular events was higher in the unattained group than in the attained group in patients without aspirin therapy; however, the incidence of cerebrovascular events in the unattained group was as low as the incidence in the attained group in patients undergoing aspirin therapy. Cox proportional hazards analysis revealed that BP level was an independent predictor for cerebrovascular events in diabetic patients.CONCLUSIONS: Aspirin therapy may reduce cerebrovascular events in diabetic patients with higher BP. Aspirin therapy could be an additional strategy as primary prevention for diabetic patients with higher BP. (日)
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| ○キーワード (推奨): | 1. | 血圧 (blood pressure)
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| 2. | (英) Cardiovascular diseases (日) (読)
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| 3. | 糖尿病 (diabetes mellitus)
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| 4. | 高血圧 (hypertension)
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| 5. | (英) Stroke (日) (読)
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| ○発行所 (推奨): | □ | 社団法人 日本循環器学会
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| ○誌名 (必須): | □ | Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
| ○ISSN (任意): | □ | 1347-4820
ISSN: 1346-9843
(pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation SocietyTitle(ISO): Circ JSupplier: 社団法人日本循環器学会Publisher: Japanese Circulation Society (NLM Catalog)
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(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 76
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 1526 1532
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 3月 25日 (平成 24年 3月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1253/circj.CJ-11-1033 (→Scopusで検索)
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| ○PMID (任意): | □ | 22447019 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84861602573
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Multicenter Study (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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