『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=287364EID:287364, Map:0, LastModified:2018年2月8日(木) 13:49:09, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yu Yaqiong (日) (読)
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2. (英) Qiu Lihong (日) (読)
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3.楊 諦
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4.岡村 裕彦
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5. (英) Guo Jiajie (日) (読)
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6.羽地 達次
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題名 (必須): (英) Tumor necrosis factor-α induces interleukin-34 expression through nuclear factor-κB  (日)    [継承]
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要約 (任意): (英) Osteoblasts produce various types of cytokines under pathological conditions and control osteoclast differentiation. Tumor necrosis factor-α (TNF-α) has been demonstrated to exert complex effects in osteoblasts under local inflammatory conditions, including in periodontal and periapical diseases. Interleukin-34 (IL-34) has been recently identified as a novel regulatory factor for the differentiation and function of osteoclasts. The present study provides the first evidence, to the best of our knowledge, that the expression of IL-34 is induced by TNF-α through nuclear factor-κB (NF-κB) activation in MC3T3-E1 osteoblastic cells. TNF-α induced IL-34 expression in a dose- and time-dependent manner. Immunocytochemistry with an NF-κB antibody demonstrated that NF-κB was mainly localized in the cytoplasm of the untreated MC3T3-E1 cells. Rapid translocation of NF-κB from the cytoplasm to the nucleus was observed in the cells treated with TNF-α for 15 min. Translocation and transcriptional activity of NF-κB were also determined by western blotting and a luciferase reporter assay, respectively. Pretreatment with 100 µM CAPE, an inhibitor of NF-κB, significantly inhibited TNF-α-induced IL-34 expression. These results indicate that TNF-α induces IL-34 expression via NF-κB in osteoblasts.  (日)    [継承]
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誌名 (必須): Molecular Medicine Reports (Spandidos Publications)
(pISSN: 1791-2997, eISSN: 1791-3004)

ISSN (任意): 1791-3004
ISSN: 1791-2997 (pISSN: 1791-2997, eISSN: 1791-3004)
Title: Molecular medicine reports
Title(ISO): Mol Med Rep
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1371 1376 [継承]
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年月日 (必須): 西暦 2014年 6月 25日 (平成 26年 6月 25日) [継承]
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DOI (任意): 10.3892/mmr.2014.2353    (→Scopusで検索) [継承]
PMID (任意): 24970360    (→Scopusで検索) [継承]
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WOS (任意): 000340854500027 [継承]
Scopus (任意): 2-s2.0-84905483670 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3892/mmr.2014.2353  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4121411  (日)    [継承]

標準的な表示

和文冊子 ● Yaqiong Yu, Lihong Qiu, Di Yang, Hirohiko Okamura, Jiajie Guo and Tatsuji Haneji : Tumor necrosis factor-α induces interleukin-34 expression through nuclear factor-κB, Molecular Medicine Reports, Vol.10, No.3, 1371-1376, 2014.
欧文冊子 ● Yaqiong Yu, Lihong Qiu, Di Yang, Hirohiko Okamura, Jiajie Guo and Tatsuji Haneji : Tumor necrosis factor-α induces interleukin-34 expression through nuclear factor-κB, Molecular Medicine Reports, Vol.10, No.3, 1371-1376, 2014.

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