『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=286299EID:286299, Map:0, LastModified:2014年10月6日(月) 09:58:44, Operator:[三好 圭子], Avail:TRUE, Censor:0, Owner:[三好 圭子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Chida Dai (日) (読)
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2.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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3. (英) Sato Tsuyoshi (日) (読)
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4. (英) Yoda Tetsuya (日) (読)
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5. (英) Kikusui Takefumi (日) (読)
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6. (英) Iwakura Yoichiro (日) (読)
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題名 (必須): (英) The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Maternal glucocorticoids are critical for fetal development, but overexpression can be deleterious. Previously we established a mouse line deficient in melanocortin receptor 2 (MC2R). MC2R(-/-) mice have undetectable levels of corticosterone despite high levels of ACTH and defects resembling those in patients with familial glucocorticoid deficiency. Here we analyzed the role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in MC2R(-/-) mice. MC2R(-/-) mice were fertile and produced normal litters when crossed with MC2R(+/+) mice. However, MC2R(-/-) females crossed with MC2R(-/-) males had no live births, and approximately 20% of the embryos at d 18.5 of pregnancy were of normal body size but were dead when born. MC2R(-/-) pregnant females crossed with MC2R(+/+) males had detectable serum corticosterone levels, suggesting the transplacental passage of corticosterone from fetus to mother. MC2R(+/-) pups delivered from MC2R(-/-) females crossed with MC2R(+/+) males mice thrived poorly with MC2R(-/-) mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R(-/-) females are poor mothers or cannot nurse. MC2R(-/-) females had normal alveoli, but penetration of mammary epithelium into fat pads and expression of milk proteins were reduced. Myoepithelial cells, which force milk out of the alveoli, were fully developed and differentiated. Pup retrieval behavior was normal in MC2R(-/-) mice. Exogenous corticosterone rescued expression of milk proteins in MC2R(-/-) mothers, and the pups of treated mothers grew to adulthood. Our results reveal the importance of glucocorticoids for fetal survival late in pregnancy, mammary gland development, and milk protein gene expression.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Female (日) (読) [継承]
3. (英) Glucocorticoids (日) (読) [継承]
4. (英) Lactation (日) (読) [継承]
5. (英) Male (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Knockout (日) (読) [継承]
8. (英) Mice, Mutant Strains (日) (読) [継承]
9. (英) Parturition (日) (読) [継承]
10. (英) Polymerase Chain Reaction (日) (読) [継承]
11. (英) Pregnancy (日) (読) [継承]
12. (英) Receptor, Melanocortin, Type 2 (日) (読) [継承]
13. (英) Receptors, Glucocorticoid (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1652 1660 [継承]
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年月日 (必須): 西暦 2011年 2月 8日 (平成 23年 2月 8日) [継承]
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DOI (任意): 10.1210/en.2010-0935    (→Scopusで検索) [継承]
PMID (任意): 21303938    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Dai Chida, Keiko Miyoshi, Tsuyoshi Sato, Tetsuya Yoda, Takefumi Kikusui and Yoichiro Iwakura : The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice., Endocrinology, Vol.152, No.4, 1652-1660, 2011.
欧文冊子 ● Dai Chida, Keiko Miyoshi, Tsuyoshi Sato, Tetsuya Yoda, Takefumi Kikusui and Yoichiro Iwakura : The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice., Endocrinology, Vol.152, No.4, 1652-1660, 2011.

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