『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=286243)

EID=286243EID:286243, Map:0, LastModified:2017年12月4日(月) 14:03:11, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[北畑 洋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.酒井 陽子 ([徳島大学.病院.中央診療施設等.麻酔科診療部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.川人 伸次 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.高石 和美 ([徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科]/[徳島大学.歯学部.歯学科.口腔疾患系臨床歯学講座.歯科麻酔学 (歯科麻酔科学講座)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.箕田 直治 ([徳島大学.病院.中央診療施設等.麻酔科診療部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kinoshita Hiroyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hatakeyama Noboru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Azma Toshiharu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.中屋 豊
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Propofol-induced relaxation of rat aorta is altered by aging.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Propofol causes vasodilation via endothelium-dependent and -independent mechanisms. Because endothelial function is impaired with aging, the effects of propofol on endothelium-dependent vasodilation might be altered by aging. The aim of this study was thus to determine the effects of aging on vascular responses to propofol. Young (4-6 weeks old) or adult (16-25 weeks old) rats were anesthetized with sevoflurane. The thoracic aorta was dissected and cut into pieces 3-4 mm in length. In some rings, the endothelium was deliberately removed. The ring segment of the aorta was mounted for isometric force recording at a resting tension of 0.5-1.0 g in a 2 ml organ bath, containing Krebs-Ringer bicarbonate buffer. Arteries were precontracted with phenylephrine, and the function of endothelium was confirmed with acetylcholine. Then, we studied the concentration-dependent effects of propofol in endothelium-intact (control group) and -denuded aortic rings (denuded group), as well as those treated with N()-nitro-L-arginine methylester (L-NAME group). Relaxation due to propofol was observed in the control groups of both young and adult rats in a concentration-dependent manner, but the magnitude of relaxation was significantly greater in young rats. In addition, in young rats, relaxation due to propofol was significantly and equally reduced in both L-NAME and denuded groups at all propofol concentrations that we studied (10(-6)-10(-3) M). In adult rats, relaxation due to propofol was quite similar between control and L-NAME groups at all propofol concentrations, whereas it was significantly reduced in the denuded group. These results suggest that endothelium-derived nitric oxide plays an important role in propofol-induced vasodilation in young rats, but not in adult rats. J. Med. Invest. 61: 278-284, August, 2014.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 61 [継承]
(必須): 3-4 [継承]
(必須): 278 284 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 8月 初日 (平成 26年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.61.278    (→Scopusで検索) [継承]
PMID (任意): 25264045    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-84907560765 [継承]
機関リポジトリ : 109571 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yoko Sakai, Shinji Kawahito, Kazumi Takaishi, Naoji Mita, Hiroyuki Kinoshita, Noboru Hatakeyama, Toshiharu Azma, Yutaka Nakaya and Hiroshi Kitahata : Propofol-induced relaxation of rat aorta is altered by aging., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 278-284, 2014.
欧文冊子 ● Yoko Sakai, Shinji Kawahito, Kazumi Takaishi, Naoji Mita, Hiroyuki Kinoshita, Noboru Hatakeyama, Toshiharu Azma, Yutaka Nakaya and Hiroshi Kitahata : Propofol-induced relaxation of rat aorta is altered by aging., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 278-284, 2014.

関連情報

Number of session users = 0, LA = 0.51, Max(EID) = 360730, Max(EOID) = 966223.