『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=286240EID:286240, Map:0, LastModified:2015年8月17日(月) 11:48:38, Operator:[北畑 洋], Avail:TRUE, Censor:0, Owner:[堤 理恵], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.堤 保夫
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2.堤 理恵 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
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3. (英) Horikawa T. Yousuke (日) (読)
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4.酒井 陽子 ([徳島大学.病院.中央診療施設等.麻酔科診療部])
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5. (英) Hamaguchi Eisuke (日) (読)
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6.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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7. (英) Kasai Asuka (日) (読)
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8. (英) Kambe Noriko (日) (読)
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9.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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題名 (必須): (英) Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Pharmacological preconditioning, including that with geranylgeranylacetone (GGA) and volatile anesthetics, has been shown to confer cardiac protection from ischemia/reperfusion injury although the mechanisms for this protection are poorly understood. Caveolins, integral membrane proteins that act as scaffolding proteins in caveolar membranes, localize molecules involved in cardiac protection. We have tested the hypothesis that caveolin-3 (Cav-3), the predominant isoform in cardiac myocytes, is essential for the synergistic effect observed between GGA and volatile anesthetics. Mice were randomly assigned to receive GGA, isoflurane [0.5 and 1.0 minimum alveolar concentration (MAC)], or GGA + isoflurane (0.5 MAC). An in vivo mouse model of ischemia/reperfusion injury was tested in wild-type and Cav-3 knockout mice, and the infarct size was determined. Biochemical assays were also performed in excised hearts. Geranylgeranylacetone and therapeutic isoflurane (1.0 MAC) independently reduced infarct size (31.6 ± 6.1 and 28.0 ± 5.0 % of the area at risk, respectively; n = 10) as compared to the controls (45.8 ± 9.4 %; n = 10). The combination GGA + sub-therapeutic isoflurane (0.5 MAC) further decreased the infarct size to 19.3 ± 5.1 % (n = 10). Preconditioning [GGA, isoflurane (1.0 MAC), and GGA + isoflurane] increased the amount of Cav-3 protein in the discontinuous sucrose-gradient buoyant fractions. Additionally, cardiac protection was not observed in Cav-3 knockout mice following the administration of GGA, isoflurane, and GGA + isoflurane. Combined administration of GGA + isoflurane had a synergistic effect, enhancing the protection against myocardial infarction to a greater extent than either drug alone. This beneficial effect is mediated by Cav-3 expression.  (日)    [継承]
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誌名 (必須): Journal of Anesthesia ([社団法人 日本麻酔科学会])
(pISSN: 0913-8668, eISSN: 1438-8359)

ISSN (任意): 1438-8359
ISSN: 0913-8668 (pISSN: 0913-8668, eISSN: 1438-8359)
Title: Journal of anesthesia
Title(ISO): J Anesth
Supplier: Springer Online Journal Archive
Publisher: Springer Japan
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 28 [継承]
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(必須): 733 739 [継承]
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年月日 (必須): 西暦 2014年 10月 1日 (平成 26年 10月 1日) [継承]
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DOI (任意): 10.1007/s00540-014-1816-8    (→Scopusで検索) [継承]
PMID (任意): 24633659    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Yasuo Tsutsumi, Rie Tsutsumi, Yousuke T. Horikawa, Yoko Sakai, Eisuke Hamaguchi, Hiroshi Kitahata, Asuka Kasai, Noriko Kambe and Katsuya Tanaka : Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, Vol.28, No.5, 733-739, 2014.
欧文冊子 ● Yasuo Tsutsumi, Rie Tsutsumi, Yousuke T. Horikawa, Yoko Sakai, Eisuke Hamaguchi, Hiroshi Kitahata, Asuka Kasai, Noriko Kambe and Katsuya Tanaka : Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, Vol.28, No.5, 733-739, 2014.

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