『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Yanuaryska Dwi Ryna (日) RYNA DWI YANUARYSKA (読) りな どぅい やぬありすか
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学籍番号 (推奨): **** [ユーザ]
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2.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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3. (英) Adiningrat Arya (日) ARYA ADININGRAT (読) ありや あでぃにんらと
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学籍番号 (推奨): **** [ユーザ]
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4.堀口 大吾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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5.谷村 綾子
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6. (英) Hagita Hiroko (日) (読)
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7.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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題名 (必須): (英) Sp6 regulation of Rock1 promoter activity in dental epithelial cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Sp6 is a transcription factor of the SP/KLF family and an indispensable regulator of the morphological dynamics of ameloblast differentiation during tooth development. However, the underlying molecular mechanisms remain unclear. We have previously identified one of the Sp6 downstream genes, Rock1, which is involved in ameloblast polarization. In this study, we investigated the transcriptional regulatory mechanisms of Rock1 by Sp6. First, we identified the transcription start sites (TSS) and cloned the 5'-flanking region of Rock1. Serial deletion analyses identified a critical region for Rock1 promoter activity within the 249-bp upstream region of TSS, and chromatin immunoprecipitation assays revealed Sp6-binding to this region. Subsequent transient transfection experiments showed that Rock1 promoter activity is enhanced by Sp6, but reduced by Sp1. Treatment of dental epithelial cells with the GC-selective DNA binding inhibitor, mithramycin A, affected Rock1 promoter activity in loss of enhancement by Sp6, but not repression by Sp1. Further site-directed mutagenesis indicated that the region from -206 to -150 contains responsive elements for Sp6. Taken together, we conclude that Sp6 positively regulates Rock1 transcription by direct binding to the Rock1 promoter region from -206 to -150, which functionally distinct from Sp1.  (日)    [継承]
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誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): VOL61 [継承]
(必須): (NO 3,4) [継承]
(必須): 306 317 [継承]
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年月日 (必須): 西暦 2014年 8月 初日 (平成 26年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.61.306    (→Scopusで検索) [継承]
PMID (任意): 25264049    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84907504213 [継承]
機関リポジトリ : 109578 [継承]
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備考 (任意): 1.(英) Article.DataBankList.DataBank.DataBankName: GENBANK  (日)    [継承]
2.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB861944  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ryna Dwi Yanuaryska, Keiko Miyoshi, Arya Adiningrat, Taigo Horiguchi, Ayako Tanimura, Hiroko Hagita and Takafumi Noma : Sp6 regulation of Rock1 promoter activity in dental epithelial cells, The Journal of Medical Investigation : JMI, Vol.VOL61, No.(NO 3,4), 306-317, 2014.
欧文冊子 ● Ryna Dwi Yanuaryska, Keiko Miyoshi, Arya Adiningrat, Taigo Horiguchi, Ayako Tanimura, Hiroko Hagita and Takafumi Noma : Sp6 regulation of Rock1 promoter activity in dental epithelial cells, The Journal of Medical Investigation : JMI, Vol.VOL61, No.(NO 3,4), 306-317, 2014.

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