『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=285827EID:285827, Map:0, LastModified:2014年10月21日(火) 16:28:38, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[西良 浩一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.江西 哲也
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2.油形 公則
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3.高橋 光彦
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4.佐藤 亮祐
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5.西良 浩一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.運動機能外科学])
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6.安井 夏生
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題名 (必須): (英) Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter.  (日)    [継承]
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要約 (任意): (英) The fate of hypertrophic chondrocytes during endochondral ossification remains controversial. It has long been thought that the calcified cartilage is invaded by blood vessels and that new bone is deposited on the surface of the eroded cartilage by newly arrived cells. The present study was designed to determine whether hypertrophic chondrocytes were destined to die or could survive to participate in new bone formation. In a rabbit experiment, a membrane filter with a pore size of 1 µm was inserted in the middle of the hypertrophic zone of the distal growth plate of ulna. In 33 of 37 animals, vascular invasion was successfully interposed by the membrane filter. During 8 days, the cartilage growth plate was enlarged, making the thickness 3-fold greater than that of the nonoperated control side. Histological examination demonstrated that the hypertrophic zone was exclusively elongated. At the terminal end of the growth plate, hypertrophic chondrocytes extruded from their territorial matrix into the open cavity on the surface of the membrane filter. The progenies of hypertrophic chondrocytes (PHCs) were PCNA positive and caspase-3 negative. In situ hybridization studies demonstrated that PHCs did not express cartilage matrix proteins anymore but expressed bone matrix proteins. Immunohistochemical studies also demonstrated that the new matrix produced by PHCs contained type I collagen, osteonectin, and osteocalcin. Based on these results, we concluded that hypertrophic chondrocytes switched into bone-forming cells after vascular invasion was interposed in the normal growth plate.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 9 [継承]
(必須): 8 [継承]
(必須): e104638 e104638 [継承]
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年月日 (必須): 西暦 2014年 8月 14日 (平成 26年 8月 14日) [継承]
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DOI (任意): 10.1371/journal.pone.0104638    (→Scopusで検索) [継承]
PMID (任意): 25121501    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0104638  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC4133260  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuya Enishi, Kiminori Yukata, Mitsuhiko Takahashi, Ryosuke Sato, Koichi Sairyo and Natsuo Yasui : Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter., PLoS ONE, Vol.9, No.8, e104638, 2014.
欧文冊子 ● Tetsuya Enishi, Kiminori Yukata, Mitsuhiko Takahashi, Ryosuke Sato, Koichi Sairyo and Natsuo Yasui : Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter., PLoS ONE, Vol.9, No.8, e104638, 2014.

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