『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=285313EID:285313, Map:0, LastModified:2015年9月5日(土) 18:25:25, Operator:[三宅 雅人], Avail:TRUE, Censor:0, Owner:[三宅 雅人], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Iwasaki Shunsuke (日) (読)
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[継承]
2.三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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[継承]
3. (英) Hayashi Shinichiro (日) (読)
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[継承]
4. (英) Watanabe Hitoshi (日) (読)
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[継承]
5. (英) Nagasawa Yuya (日) (読)
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[継承]
6. (英) Terada Shunsuke (日) (読)
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[継承]
7. (英) Watanabe Kouichi (日) (読)
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8. (英) Ohwada Shyuichi (日) (読)
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[継承]
9. (英) Kitazawa Haruki (日) (読)
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10. (英) Rose T. Michael (日) (読)
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11. (英) Aso Hisashi (日) (読)
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[継承]
題名 (必須): (英) Effect of myostatin on chemokine expression in regenerating skeletal muscle cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Transforming growth factor- (TGF-) is implicated in the regulatory expression of chemokines that control multiple steps in myogenesis. However, it remains to be established whether myostatin, a member of the TGF- superfamily, affects chemokine expression in skeletal muscle. We investigated the effects of myostatin on the expression of mRNAs and proteins for 4 chemokines (CXCL1, CXCL2, CXCL6, CCL2) in intact and regenerating musculus longissimus thoracis from normal-muscled (NM) and double-muscled (DM) cattle. These chemokines were expressed in regenerating muscle, and their expression was always lower in DM than in NM cattle. Immunohistochemistry revealed that CXCL1 and CXCL6 were detected in the regenerating areas of myoblasts and myotubes in both NM and DM cattle. In cultures of myoblasts isolated from the regenerating muscles, significantly less CXCL1, CXCL2 and CCL2 mRNA was expressed in DM myoblasts than in NM myoblasts during the proliferating stage (P-stage). The expression of CXCL1, CXCL2 and CCL2 mRNAs in NM myoblasts and CXCL1, CXCL2 and CXCL6 mRNAs in DM myoblasts decreased upon switching from P-stage to fusion stage (F-stage). Also, the expression of CXCL1, CXCL2 and CXCL6 mRNAs was significantly lower in DM than in NM myoblasts during the F-stage. The addition of 100 ng/ml myostatin during the F-stage attenuated the expression of CXCL1 and CXCL2 mRNAs and augmented that of CCL2. These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cattle (日) (読) [継承]
3. (英) Cell Proliferation (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Chemokines (日) (読) [継承]
6. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
7. (英) Muscle Development (日) (読) [継承]
8. (英) Muscle, Skeletal (日) (読) [継承]
9. (英) Myoblasts (日) (読) [継承]
10. (英) Myostatin (日) (読) [継承]
11. (英) RNA, Messenger (日) (読) [継承]
12. (英) Regeneration (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cells, Tissues, Organs ([Karger])
(pISSN: 1422-6405, eISSN: 1422-6421)

ISSN (任意): 1422-6421
ISSN: 1422-6405 (pISSN: 1422-6405, eISSN: 1422-6421)
Title: Cells, tissues, organs
Title(ISO): Cells Tissues Organs
Publisher: S. Karger AG
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1 [継承]
(必須): 66 74 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 7月 3日 (平成 25年 7月 3日) [継承]
URL (任意):
DOI (任意): 10.1159/000351462    (→Scopusで検索) [継承]
PMID (任意): 23838214    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1159/000351462  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shunsuke Iwasaki, Masato Miyake, Shinichiro Hayashi, Hitoshi Watanabe, Yuya Nagasawa, Shunsuke Terada, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose and Hisashi Aso : Effect of myostatin on chemokine expression in regenerating skeletal muscle cells., Cells, Tissues, Organs, Vol.198, No.1, 66-74, 2013.
欧文冊子 ● Shunsuke Iwasaki, Masato Miyake, Shinichiro Hayashi, Hitoshi Watanabe, Yuya Nagasawa, Shunsuke Terada, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose and Hisashi Aso : Effect of myostatin on chemokine expression in regenerating skeletal muscle cells., Cells, Tissues, Organs, Vol.198, No.1, 66-74, 2013.

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