『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=285182EID:285182, Map:0, LastModified:2015年11月2日(月) 15:02:00, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[堤 理恵], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.堤 理恵 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
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2. (英) Yoshida Tomomi (日) (読)
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3. (英) Nii Yoshitaka (日) (読)
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4. (英) Okahisa Naoki (日) (読)
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5.岩田 深也
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6.津嘉山 正夫
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7. (英) Hashimoto Rei (日) (読)
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8. (英) Taniguchi Yasuko (日) (読)
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9.阪上 浩 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[徳島大学.糖尿病臨床・研究開発センター])
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10.保坂 利男
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11.首藤 恵泉
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12.酒井 徹 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])
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題名 (必須): (英) Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose, lipid, and energy metabolism in mice with high-fat diet-induced obesity and db/db diabetic mice. In our current study, we show that sudachitin improves metabolism and stimulates mitochondrial biogenesis, thereby increasing energy expenditure and reducing weight gain. C57BL/6 J mice fed a high-fat diet (40% fat) and db/db mice fed a normal diet were treated orally with 5 mg/kg sudachitin or vehicle for 12 weeks. Following treatment, oxygen expenditure was assessed using indirect calorimetry, while glucose tolerance, insulin sensitivity, and indices of dyslipidemia were assessed by serum biochemistry. Quantitative polymerase chain reaction was used to determine the effect of sudachitin on the transcription of key metabolism-regulating genes in the skeletal muscle, liver, and white and brown adipose tissues. Primary myocytes were also prepared to examine the signaling mechanisms targeted by sudachitin in vitro. Sudachitin improved dyslipidemia, as evidenced by reduction in triglyceride and free fatty acid levels, and improved glucose tolerance and insulin resistance. It also enhanced energy expenditure and fatty acid β-oxidation by increasing mitochondrial biogenesis and function. The in vitro assay results suggest that sudachitin increased Sirt1 and PGC-1α expression in the skeletal muscle. Sudachitin may improve dyslipidemia and metabolic syndrome by improving energy metabolism. Furthermore, it also induces mitochondrial biogenesis to protect against metabolic disorders.  (日)    [継承]
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誌名 (必須): Nutrition & Metabolism ([BioMed Central Ltd.])
(eISSN: 1743-7075)

ISSN (任意): 1743-7075
ISSN: 1743-7075 (eISSN: 1743-7075)
Title: Nutrition & metabolism
Title(ISO): Nutr Metab (Lond)
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 11 [継承]
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(必須): 32 32 [継承]
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年月日 (必須): 西暦 2014年 7月 4日 (平成 26年 7月 4日) [継承]
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DOI (任意): 10.1186/1743-7075-11-32    (→Scopusで検索) [継承]
PMID (任意): 25114710    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1186/1743-7075-11-32  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4128574  (日)    [継承]
4.(英) KeywordList.Keyword: Glucose metabolism  (日)    [継承]
5.(英) KeywordList.Keyword: Lipid metabolism  (日)    [継承]
6.(英) KeywordList.Keyword: Mitochondria  (日)    [継承]
7.(英) KeywordList.Keyword: Sudachitin  (日)    [継承]

標準的な表示

和文冊子 ● Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto and Tohru Sakai : Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle., Nutrition & Metabolism, Vol.11, 32, 2014.
欧文冊子 ● Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto and Tohru Sakai : Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle., Nutrition & Metabolism, Vol.11, 32, 2014.

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