『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=284884)

EID=284884EID:284884, Map:0, LastModified:2014年10月30日(木) 15:35:59, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[竹谷 豊], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kozai Mina (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.山本 浩範
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ishiguro Mariko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.原田 永勝
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Masuda Masashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Kagawa Tomohiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Takei Yuichiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Otani Ayako (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Nakahashi Otoki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Ikeda Shoko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
11.竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
12. (英) Takeyama Ken-Ichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
13. (英) Kato Shigeaki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
14.武田 英二
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Thyroid hormones decrease plasma 1,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D3 1-hydroxylase gene (CYP27B1).  (日)    [継承]
副題 (任意):
要約 (任意): (英) The primary determinant of circulating 1,25-dihydroxyvitamin D (1,25[OH](2)D) levels is the activity of 25-hydroxyvitamin D-1-hydroxylase (cytochrome P450 27B1 [CYP27B1]) in the kidney. Hyperthyroid patients have been reported to have low levels of plasma 1,25(OH)(2)D. However, the detailed mechanism of thyroid hormone action on vitamin D metabolism is still poorly understood. The present study determined whether renal CYP27B1 gene expression was negatively regulated by thyroid hormones. T(3)-induced hyperthyroid mice showed marked decreases in plasma 1,25(OH)(2)D levels and in renal expression of CYP27B1 mRNA but no changes in plasma concentrations of calcium, PTH, or fibroblast growth factor-23. In addition, we observed that T(3) administration significantly decreased plasma 1,25(OH)(2)D and renal CYP27B1 mRNA levels that were increased by low-calcium or low-phosphorus diets and induced hypocalcemia in mice fed a low-calcium diet. Promoter analysis revealed that T(3) decreases the basal transcriptional activity of the CYP27B1 gene through thyroid hormone receptors (TR and TR1) and the retinoid X receptor (RXR) in renal proximal tubular cells. Interestingly, we identified an everted repeat negative thyroid hormone response element (1-nTRE) overlapping the sterol regulatory element (1-SRE) and the TATA-box -50 to -20 base pairs from the human CYP27B1 gene transcription start site. Finally, we established that CYP27B1 gene transcription is positively regulated by SRE-binding proteins and that a T(3)-bound TR1/RXR heterodimer inhibits SRE-binding protein-1c-induced transcriptional activity through the 1-nTRE. These results suggest that transcriptional repression of the CYP27B1 gene by T(3)-bound TRs/RXR, acting through the 1-nTRE, results in decreased renal CYP27B1 expression and plasma 1,25(OH)(2)D levels.  (日)    [継承]
キーワード (推奨): 1. (英) 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Calcitriol (日) (読) [継承]
4. (英) Enzyme Repression (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Kidney (日) (読) [継承]
7. (英) Kidney Tubules, Proximal (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) Response Elements (日) (読) [継承]
11. (英) Thyroid Hormones (日) (読) [継承]
12. (英) Transcription, Genetic (日) (読) [継承]
13. (英) Triiodothyronine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 154 [継承]
(必須): 2 [継承]
(必須): 609 622 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 1月 10日 (平成 25年 1月 10日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2012-1647    (→Scopusで検索) [継承]
PMID (任意): 23307792    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000313959800007 [継承]
Scopus (任意): 2-s2.0-84872702811 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mina Kozai, Hironori Yamamoto, Mariko Ishiguro, Nagakatsu Harada, Masashi Masuda, Tomohiro Kagawa, Yuichiro Takei, Ayako Otani, Otoki Nakahashi, Shoko Ikeda, Yutaka Taketani, Ken-Ichi Takeyama, Shigeaki Kato and Eiji Takeda : Thyroid hormones decrease plasma 1,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D3 1-hydroxylase gene (CYP27B1)., Endocrinology, Vol.154, No.2, 609-622, 2013.
欧文冊子 ● Mina Kozai, Hironori Yamamoto, Mariko Ishiguro, Nagakatsu Harada, Masashi Masuda, Tomohiro Kagawa, Yuichiro Takei, Ayako Otani, Otoki Nakahashi, Shoko Ikeda, Yutaka Taketani, Ken-Ichi Takeyama, Shigeaki Kato and Eiji Takeda : Thyroid hormones decrease plasma 1,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D3 1-hydroxylase gene (CYP27B1)., Endocrinology, Vol.154, No.2, 609-622, 2013.

関連情報

Number of session users = 0, LA = 0.59, Max(EID) = 383334, Max(EOID) = 1024616.