| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nakajima Shoko (日) (読)
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| 2. | 成戸 卓也
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| 3. | (英) Miyamae Takako (日) (読)
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| 4. | (英) Imagawa Tomoyuki (日) (読)
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| 5. | (英) Mori Masaaki (日) (読)
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| 6. | (英) Nishimaki Shigeru (日) (読)
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| 7. | (英) Yokota Shumpei (日) (読)
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| ○題名 (必須): | □ | (英) Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells. (日)
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| ○要約 (任意): | □ | (英) Interleukin (IL)-6 is a causative agent of systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease complicated with severe growth impairment. Recent trials of anti-IL-6 receptor monoclonal antibody, tocilizumab, indicated that tocilizumab blocks IL-6/IL-6 receptor-mediated inflammation, and induces catch-up growth in children with sJIA. This study evaluates the effects of IL-6 on chondrogenesis by ATDC5 cells, a clonal murine chondrogenic cell line that provides an excellent model for studying endochondral ossification at growth plate. ATDC5 cells were examined for the expression of IL-6 receptor and gp130 by fluorescence-activated cell sorting analysis. Recombinant murine IL-6 was added to ATDC5 cultures to observe cell differentiation, using a quantitative RT-PCR for the chondrogenic differentiation markers type II collagen, aggrecan, and type X collagen. To block IL-6, the anti-mouse IL-6 receptor monoclonal antibody MR16-1 was added. As a result, the cells expressed IL-6 receptor and gp130. The expression of chondrogenic differentiation marker gene was reduced by IL-6, but this was abrogated by MR16-1. We conclude that IL-6 inhibits early chondrogenesis of ATDC5 cells suggesting that IL-6 may affect committed stem cells at a cellular level during chondrogenic differentiation of growth plate chondrocytes, and that IL-6 may be a cellular-level factor in growth impairment in sJIA. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Biological Markers (日) (読)
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| 3. | (英) Cartilage (日) (読)
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| 4. | 細胞分化 (cell differentiation)
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| 5. | (英) Cell Line, Tumor (日) (読)
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| 6. | (英) Cell Proliferation (日) (読)
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| 7. | (英) Chondrocytes (日) (読)
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| 8. | (英) Chondrogenesis (日) (読)
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| 9. | (英) Cytokine Receptor gp130 (日) (読)
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| 10. | 遺伝子発現 (gene expression)
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| 11. | (英) Interleukin-6 (日) (読)
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| 12. | (英) Mice (日) (読)
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| 13. | (英) Receptors, Interleukin-6 (日) (読)
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| 14. | (英) Stem Cells (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cytokine (International Cytokine Society)
(pISSN: 1043-4666, eISSN: 1096-0023)
| ○ISSN (任意): | □ | 1096-0023
ISSN: 1043-4666
(pISSN: 1043-4666, eISSN: 1096-0023) Title: CytokineTitle(ISO): CytokinePublisher: Academic Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 47
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 91 97
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 6月 16日 (平成 21年 6月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.cyto.2009.05.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 19535264 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-67650594920
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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