『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=284156EID:284156, Map:0, LastModified:2015年6月26日(金) 15:34:52, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[近久 幸子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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2. (英) Shimizu Noriyuki (日) (読)
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3.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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4.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Ketone body metabolism and sleep homeostasis in mice.  (日)    [継承]
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要約 (任意): (英) A link has been established between energy metabolism and sleep homeostasis. The ketone bodies acetoacetate and -hydroxybutyrate, generated from the breakdown of fatty acids, are major metabolic fuels for the brain under conditions of low glucose availability. Ketogenesis is modulated by the activity of peroxisome proliferator-activated receptor alpha (PPAR), and treatment with a PPAR activator has been shown to induce a marked increase in plasma acetoacetate and decreased -hydroxybutyrate in mice, accompanied by increased slow-wave activity during non-rapid eye movement (NREM) sleep. The present study investigated the role of ketone bodies in sleep regulation. Six-hour sleep deprivation increased plasma ketone bodies and their ratio (acetoacetate/-hydroxybutyrate) in 10-week-old male mice. Moreover, sleep deprivation increased mRNA expression of ketogenic genes such as PPAR and 3-hydroxy-3-methylglutarate-CoA synthase 2 in the brain and decreased ketolytic enzymes such as succinyl-CoA: 3-oxoacid CoA transferase. In addition, central injection of acetoacetate, but not -hydroxybutyrate, markedly increased slow-wave activity during NREM sleep and suppressed glutamate release. Central metabolism of ketone bodies, especially acetoacetate, appears to play a role in the regulation of sleep homeostasis.  (日)    [継承]
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誌名 (必須): Neuropharmacology ([Pergamon Press])
(pISSN: 0028-3908, eISSN: 1873-7064)

ISSN (任意): 1873-7064
ISSN: 0028-3908 (pISSN: 0028-3908, eISSN: 1873-7064)
Title: Neuropharmacology
Title(ISO): Neuropharmacology
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 79 [継承]
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(必須): 399 404 [継承]
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年月日 (必須): 西暦 2014年 4月 末日 (平成 26年 4月 末日) [継承]
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DOI (任意): 10.1016/j.neuropharm.2013.12.009    (→Scopusで検索) [継承]
PMID (任意): 24361452    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84891783926 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei : Ketone body metabolism and sleep homeostasis in mice., Neuropharmacology, Vol.79, (号), 399-404, 2014.
欧文冊子 ● Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi and Hiroyoshi Sei : Ketone body metabolism and sleep homeostasis in mice., Neuropharmacology, Vol.79, (号), 399-404, 2014.

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