『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=284151EID:284151, Map:0, LastModified:2014年10月21日(火) 16:33:50, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[近久 幸子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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2. (英) Kodama Tohru (日) (読)
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3. (英) Soya Atsushi (日) (読)
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4. (英) Sagawa Yohei (日) (読)
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5. (英) Ishimaru Yuji (日) (読)
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6.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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7. (英) Nishino Seiji (日) (読)
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題名 (必須): (英) Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states.  (日)    [継承]
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要約 (任意): (英) Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells, mediators from brain mast cells may significantly influence sleep and other behaviors. In this study, we examined potential involvement of brain mast cells in sleep/wake regulations, focusing especially on the histaminergic system, using mast cell deficient (W/W(v)) mice. No significant difference was found in the basal amount of sleep/wake between W/W(v) mice and their wild-type littermates (WT), although W/W(v) mice showed increased EEG delta power and attenuated rebound response after sleep deprivation. Intracerebroventricular injection of compound 48/80, a histamine releaser from mast cells, significantly increased histamine levels in the ventricular region and enhanced wakefulness in WT mice, while it had no effect in W/W(v) mice. Injection of H1 antagonists (triprolidine and mepyramine) significantly increased the amounts of slow-wave sleep in WT mice, but not in W/W(v) mice. Most strikingly, the food-seeking behavior observed in WT mice during food deprivation was completely abolished in W/W(v) mice. W/W(v) mice also exhibited higher anxiety and depression levels compared to WT mice. Our findings suggest that histamine released from brain mast cells is wake-promoting, and emphasizes the physiological and pharmacological importance of brain mast cells in the regulation of sleep and fundamental neurobehavior.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS ONE
Publisher: Public Library of Science
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 8 [継承]
(必須): 10 [継承]
(必須): e78434 e78434 [継承]
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年月日 (必須): 西暦 2013年 10月 18日 (平成 25年 10月 18日) [継承]
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DOI (任意): 10.1371/journal.pone.0078434    (→Scopusで検索) [継承]
PMID (任意): 24205232    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0078434  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC3800008  (日)    [継承]

標準的な表示

和文冊子 ● Sachiko Chikahisa, Tohru Kodama, Atsushi Soya, Yohei Sagawa, Yuji Ishimaru, Hiroyoshi Sei and Seiji Nishino : Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states., PLoS ONE, Vol.8, No.10, e78434, 2013.
欧文冊子 ● Sachiko Chikahisa, Tohru Kodama, Atsushi Soya, Yohei Sagawa, Yuji Ishimaru, Hiroyoshi Sei and Seiji Nishino : Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states., PLoS ONE, Vol.8, No.10, e78434, 2013.

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