『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kashiwagi Masayuki (日) (読)
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2.石上 安希子
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3. (英) Hara Kenji (日) (読)
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4. (英) Matsusue Aya (日) (読)
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5. (英) Waters Brian (日) (読)
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6. (英) Takayama Mio (日) (読)
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7.徳永 逸夫
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8.西村 明儒 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.法医学])
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9.久保 真一
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題名 (必須): (英) Immunohistochemical investigation of the coma blister and its pathogenesis  (日)    [継承]
副題 (任意):
要約 (任意): (英) The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Autopsy (日) (読) [継承]
4. (英) Biological Markers (日) (読) [継承]
5. (英) Blister (日) (読) [継承]
6. (英) Coma (日) (読) [継承]
7. (英) Drug Overdose (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Skin (日) (読) [継承]
12. (英) Sweat Glands (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 60 [継承]
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(必須): 256 261 [継承]
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年月日 (必須): 西暦 2013年 0月 初日 (平成 25年 0月 初日) [継承]
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DOI (任意): 10.2152/jmi.60.256    (→Scopusで検索) [継承]
PMID (任意): 24190044    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84887001165 [継承]
機関リポジトリ : 106365 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Masayuki Kashiwagi, Akiko Ishigami, Kenji Hara, Aya Matsusue, Brian Waters, Mio Takayama, Itsuo Tokunaga, Akiyoshi Nishimura and Shin-ichi Kubo : Immunohistochemical investigation of the coma blister and its pathogenesis, The Journal of Medical Investigation : JMI, Vol.60, No.3,4, 256-261, 2013.
欧文冊子 ● Masayuki Kashiwagi, Akiko Ishigami, Kenji Hara, Aya Matsusue, Brian Waters, Mio Takayama, Itsuo Tokunaga, Akiyoshi Nishimura and Shin-ichi Kubo : Immunohistochemical investigation of the coma blister and its pathogenesis, The Journal of Medical Investigation : JMI, Vol.60, No.3,4, 256-261, 2013.

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