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種別 (必須):
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Guo Jun (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Song Lige (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Liu Minlin (日) (読)
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[継承]
4.瀬川 博子 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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5.宮本 賢一
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6. (英) Bringhurst F Richard (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Kronenberg Henry M (日) (読)
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[継承]
8. (英) Jüppner Harald (日) (読)
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題名 (必須): (英) Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) PTH increases urinary Pi excretion by reducing expression of two renal cotransporters [NaPi-IIa (Npt2a) and NaPi-IIc (Npt2c)]. In contrast to acute transporter regulation that is cAMP/protein kinase A dependent, long-term effects require phospholipase C (PLC) signaling by the PTH/PTHrP receptor (PPR). To determine whether the latter pathway regulates Pi through Npt2a and/or Npt2c, wild-type mice (Wt) and animals expressing a mutant PPR incapable of PLC activation (DD) were tested in the absence of one (Npt2a(-/-) or Npt2c(-/-)) or both phosphate transporters (2a/2c-dko). PTH infusion for 8 days caused a rapid and persistent decrease in serum Pi in Wt mice, whereas serum Pi in DD mice fell only transiently for the first 2 days. Consistent with these findings, fractional Pi excretion index was increased initially in both animals, but this increase persisted only when the PPR Wt was present. The hypophosphatemic response to PTH infusion was impaired only slightly in PPR Wt/Npt2c(-/-) or DD/Npt2c(-/-) mice. Despite lower baselines, PTH infusion in PPR Wt/Npt2a(-/-) mice decreased serum Pi further, an effect that was attenuated in DD/Npt2a(-/-) mice. Continuous PTH had no effect on serum Pi in 2a/2c-dko mice. PTH administration increased serum 1,25 dihydroxyvitamin D3 levels in Wt and DD mice and increased levels above the elevated baseline with ablation of either but not of both transporters. Continuous PTH elevated serum fibroblast growth factor 23 and blood Ca(2+) equivalently in all groups of mice. Our data indicate that PLC signaling at the PPR contributes to the long-term effect of PTH on Pi homeostasis but not to the regulation of 1,25 dihydroxyvitamin D3, fibroblast growth factor 23, or blood Ca(2+).  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cyclic AMP (日) (読) [継承]
3. (英) Cyclic AMP-Dependent Protein Kinases (日) (読) [継承]
4. (英) Hypophosphatemia (日) (読) [継承]
5. (英) Infusions, Intravenous (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Inbred C57BL (日) (読) [継承]
9. (英) Mice, Knockout (日) (読) [継承]
10. (英) Mutation (日) (読) [継承]
11. (英) Parathyroid Hormone (日) (読) [継承]
12. (英) Receptor, Parathyroid Hormone, Type 1 (日) (読) [継承]
13. (英) Signal Transduction (日) (読) [継承]
14. (英) Sodium-Phosphate Cotransporter Proteins, Type IIa (日) (読) [継承]
15. (英) Sodium-Phosphate Cotransporter Proteins, Type IIc (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 154 [継承]
(必須): 5 [継承]
(必須): 1680 1689 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 3月 20日 (平成 25年 3月 20日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2012-2240    (→Scopusで検索) [継承]
PMID (任意): 23515284    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000317908800003 [継承]
Scopus (任意): 2-s2.0-84876756044 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Jun Guo, Lige Song, Minlin Liu, Hiroko Segawa, Ken-ichi Miyamoto, Richard F Bringhurst, M Henry Kronenberg and Harald Jüppner : Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice., Endocrinology, Vol.154, No.5, 1680-1689, (発行所), (都市), March 2013.
欧文冊子 ● (種別) : Jun Guo, Lige Song, Minlin Liu, Hiroko Segawa, Ken-ichi Miyamoto, Richard F Bringhurst, M Henry Kronenberg and Harald Jüppner : Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice., Endocrinology, Vol.154, No.5, 1680-1689, (発行所), (都市), March 2013.

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