| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 2. | (英) Maruyama Satoshi (日) (読)
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| 3. | 佐々木 由紀 ([徳島大学.AWAサポートセンター])
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| 4. | (英) Yagita Hideo (日) (読)
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| 5. | (英) Hozumi Katsuto (日) (読)
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| 6. | (英) Tomita Taisuke (日) (読)
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| 7. | (英) Kishihara Kenji (日) (読)
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| 8. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling. (日)
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| ○要約 (任意): | □ | (英) The gastrointestinal tract comes into direct contact with environmental agents, including bacteria, viruses, and foods. Intestine-specific subsets of immune cells maintain gut homeostasis by continuously sampling luminal antigens and maintaining immune tolerance. CD11c(+)CX3CR1(+) cells sample luminal antigens in the small intestine and contribute to the trafficking of bacteria to lymph nodes under dysbiotic conditions. The molecular mechanisms crucial for the differentiation of CD11c(+)CX3CR1(+) cells remain unclear. Here we demonstrate that the Notch1- or Notch2-Rbpj axis is essential for the development of CD11c(+)CX3CR1(+) cells. In mice in which Rbpj or Notch1 and Notch2 were deleted from CD11c(+) cells, there was a deficit of CD11c(+)CX3CR1(+) cells and an accumulation of CD11c(low)CX3CR1(+) cells. The CD11c(low)CX3CR1(+) cells could not differentiate to CD11c(+)CX3CR1(+) cells, suggesting that CD11c(low)CX3CR1(+) cells represent a lineage distinct from CD11c(+)CX3CR1(+) cells. These data indicate that Notch signaling is essential for lineage fixation of intestinal CD11c(+)CX3CR1(+) cells. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD11c (日) (読)
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| 3. | (英) Cell Count (日) (読)
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| 4. | (英) Cell Differentiation (日) (読)
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| 5. | (英) Immunoglobulin J Recombination Signal Sequence-Binding Protein (日) (読)
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| 6. | (英) Intestine, Small (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Mice, Inbred C57BL (日) (読)
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| 9. | (英) Receptors, Chemokine (日) (読)
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| 10. | (英) Receptors, Notch (日) (読)
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| 11. | (英) Signal Transduction (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 1091-6490
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 111
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| ○号 (必須): | □ | 16
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| ○頁 (必須): | □ | 5986 5991
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 4月 7日 (平成 26年 4月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.1401671111 (→Scopusで検索)
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| ○PMID (任意): | □ | 24711412 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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