| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Bhuyan Zaied Ahmed (日) Bhuyan Zaied Ahmed (読) ぶや ざいど あはまど
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 3. | 西田 純
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| 4. | 片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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| 5. | (英) Kurihara Takeshi (日) 栗原 健士 (読) くりはら たけし
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 7. | (英) Tsumura Hideki (日) (読)
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| 8. | (英) Ito Morihiro (日) (読)
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| 9. | (英) Ito Yasuhiko (日) (読)
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| 10. | 北村 明子
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| 11. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) CD4(+) T cell activation is controlled by signaling through the T cell receptor in addition to various co-receptors, and is also affected by their interactions with effector and regulatory T cells in the microenvironment. Inflammatory bowel diseases (IBD) are caused by the persistent activation and expansion of auto-aggressive CD4(+) T cells that attack intestinal epithelial cells. However, the molecular basis for the persistent activation of CD4(+) T cells in IBD remains unclear. In this study, we investigated how the CD98 heavy chain (CD98hc, Slc3a2) affected the development of colitis in an experimental animal model. Transferring CD98hc-deficient CD4(+)CD25(-) T cells into Rag2(-/-) mice did not cause colitis accompanied by increasing Foxp3(+) inducible regulatory T cells. By comparison, CD98hc-deficient naturally occurring regulatory T cells (nTregs) had a decreased capability to suppress colitis induced by CD4(+)CD25(-) T cells, although CD98hc-deficient mice did not have a defect in the development of nTregs. Blocking CD98hc with an anti-CD98 blocking antibody prevented the development of colitis. Our results indicate that CD98hc regulates the expansion of autoimmune CD4(+) T cells in addition to controlling nTregs functions, which suggests the CD98hc as an important target molecule for establishing strategies for treating colitis. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD98 Heavy Chain (日) (読)
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| 3. | (英) Autoimmune Diseases (日) (読)
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| 4. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 5. | (英) Colitis (日) (読)
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| 6. | (英) Colon (日) (読)
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| 7. | (英) DNA-Binding Proteins (日) (読)
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| 8. | (英) Gene Deletion (日) (読)
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| 9. | (英) Interleukin-2 Receptor alpha Subunit (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Mice, Inbred BALB C (日) (読)
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| 12. | (英) Mice, Inbred C57BL (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 1090-2104
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 444
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 628 633
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 1月 31日 (平成 26年 1月 31日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrc.2014.01.144 (→Scopusで検索)
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| ○PMID (任意): | □ | 24491544 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000332433100031
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| ○Scopus (任意): | □ | 2-s2.0-84894522828
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| ○評価値 (任意): |
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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