『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=281805EID:281805, Map:0, LastModified:2016年2月5日(金) 13:19:36, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ソシオテクノサイエンス研究部.ライフシステム部門 (2006年4月1日〜) [継承]
著者 (必須): 1. (英) Abe Chiaki (日) (読)
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2.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
3. (英) Kawasaki Ayaka (日) (読)
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[継承]
4. (英) Noguchi Chiho (日) (読)
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[継承]
5. (英) Tanaka Ryo (日) (読)
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[継承]
6. (英) Yoshitomi Toru (日) (読)
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[継承]
7. (英) Nagasaki Yukio (日) (読)
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[継承]
8. (英) Endo Yoshio (日) (読)
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[継承]
9.堀 均
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[継承]
題名 (必須): (英) Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model  (日)    [継承]
副題 (任意):
要約 (任意): (英) Antioxidants have been demonstrated to exert beneficial effects as pharmacotherapies for cardiovascular diseases. The in vitro systems generally employed to evaluate antioxidants, however, are limited by having no appreciable in vivo redox status of the antioxidants. Therefore, we used our developing chicken egg model to evaluate the in vivo antioxidative activity of a redox nanoparticle possessing 2,2,6,6-tetramethylpiperidine-1-oxyl (RNP(O)). The 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) elicited strong oxidative stress and its LD50 value for chick embryos was 3.5±0.9mg/egg. The low molecular weight nitroxide compound, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), which is known to have the highest level of antioxidant activity, showed no significant protective effect against AAPH-induced embryo lethality. On the contrary, RNP(O) had potent protective effects against AAPH-induced embryo lethality. Moreover, RNP(O) could significantly suppress the production of lipid peroxides in chick serum induced by hydrocortisone. Since RNP(O) has a longer retention time in blood than TEMPOL, RNP(O) may protect the embryo against lethal oxidative stress by suppressing lipid peroxidation. The validity of in vivo experiments using developing chicken eggs was supported by our data, where RNP(O) was determined to elicit strong antioxidative activity in vivo, irrespective of the lack of a significant difference in the in vitro activity between low-molecular weight TEMPOL and RNP(O). Our results support the use of the developing chicken egg model to evaluate the potential in vivo antioxidative activity of RNP(O).  (日)    [継承]
キーワード (推奨): 1.抗酸化物質 (antioxidant) [継承]
2. (英) redox nanoparticle (日) (読) [継承]
3. (英) chick embryo (日) (読) [継承]
4.薬物速度論 (pharmacokinetics) [継承]
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): Journal of Controlled Release (Controlled Release Society)
(pISSN: 0168-3659, eISSN: 1873-4995)

ISSN (任意): 1873-4995
ISSN: 0168-3659 (pISSN: 0168-3659, eISSN: 1873-4995)
Title: Journal of controlled release : official journal of the Controlled Release Society
Title(ISO): J Control Release
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 182 [継承]
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(必須): 67 72 [継承]
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年月日 (必須): 西暦 2014年 5月 28日 (平成 26年 5月 28日) [継承]
URL (任意):
DOI (任意): 10.1016/j.jconrel.2014.03.015    (→Scopusで検索) [継承]
PMID (任意): 24637467    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000335554000007 [継承]
Scopus (任意): 2-s2.0-84897382722 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, 2-1 Minamijosanjimacho, Tokushima 770-8506, Japan. uto@bio.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Chiaki Abe, Yoshihiro Uto, Ayaka Kawasaki, Chiho Noguchi, Ryo Tanaka, Toru Yoshitomi, Yukio Nagasaki, Yoshio Endo and Hitoshi Hori : Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model, Journal of Controlled Release, Vol.182, 67-72, 2014.
欧文冊子 ● Chiaki Abe, Yoshihiro Uto, Ayaka Kawasaki, Chiho Noguchi, Ryo Tanaka, Toru Yoshitomi, Yukio Nagasaki, Yoshio Endo and Hitoshi Hori : Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model, Journal of Controlled Release, Vol.182, 67-72, 2014.

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