『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=281604EID:281604, Map:0, LastModified:2016年2月18日(木) 14:17:58, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[北畑 洋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Mio Yasushi (日) (読)
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[継承]
2. (英) Uezono Shoichi (日) (読)
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3.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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題名 (必須): (英) Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Anesthetic pre- and postconditioning pharmacologically reduce ischemia/reperfusion injury. Mitochondria play a central role in these myocardial protective salvage effects. In the preconditioning, low levels of reactive oxygen species, which are produced by anesthetics in the mitochondria, act as a trigger to prevent cardiomyocytes death and modify intracellular signaling mechanisms. In the postconditioning, decreased mitochondrial matrix pH, which was caused by anesthetics, triggers the onset of a rapid protective effect. The mitochondrial membranes have several ion channels that act as major determining factors of cellular life and death under pathophysiological conditions. In these channels, the mitochondrial adenosine triphosphate-sensitive K+ channels, the mitochondrial Ca2+-activated K+ channels and mitochondrial permeability transition pores play critical roles in cardioprotection against ischemia/reperfusion injury. Mitochondrial permeability transition pores are end effectors, which contribute to myocardial preconditioning and postconditioning. Activation of intracellular signaling and acidification of mitochondrial matrix pH prevent the mitochondrial permeability transition pore opening, and therefore, preserve the mitochondrial function to supply adenosine triphosphate, resulting in myocardial protection due to the maintenance of intracellular homeostasis.  (日)    [継承]
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誌名 (必須): Current Pharmaceutical Design (Bentham Science Publishers)
(pISSN: 1381-6128, eISSN: 1873-4286)

ISSN (任意): 1873-4286
ISSN: 1381-6128 (pISSN: 1381-6128, eISSN: 1873-4286)
Title: Current pharmaceutical design
Title(ISO): Curr. Pharm. Des.
Publisher: Bentham Science Publishers
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 20 [継承]
(必須): 36 [継承]
(必須): 5673 5680 [継承]
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年月日 (必須): 西暦 2014年 2月 初日 (平成 26年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.2174/1381612820666140204110101    (→Scopusで検索) [継承]
PMID (任意): 24502577    (→Scopusで検索) [継承]
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WOS (任意): 000342006100002 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Yasushi Mio, Shoichi Uezono and Hiroshi Kitahata : Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science., Current Pharmaceutical Design, Vol.20, No.36, 5673-5680, Feb. 2014.
欧文冊子 ● Yasushi Mio, Shoichi Uezono and Hiroshi Kitahata : Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science., Current Pharmaceutical Design, Vol.20, No.36, 5673-5680, Feb. 2014.

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