『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.吉川 幸造 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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2.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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3.桑原 知巳
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4. (英) Hirakawa Hideki (日) (読)
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5.栗田 信浩
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6.佐藤 宏彦
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7.宇都宮 徹
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8.岩田 貴 ([徳島大学.教養教育院])
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9.宮谷 知彦
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10.東島 潤
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11. (英) Kashihara Hideya (日) (読)
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12.髙須 千絵 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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13. (英) Matsumoto Noriko (日) (読)
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14. (英) Nakayama-Imaohji Haruyuki (日) (読)
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題名 (必須): (英) Effect of Kampo medicine "Dai-kenchu-to" on microbiome in the intestine of the rats with fast stress.  (日)    [継承]
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要約 (任意): (英) Diversity of gut microbiome has been recently reported to be lost in inflammatory bowel disease. We have previously reported that the Dai-kenchu-to (DKT) prevented the bacterial translocation through suppression of cytokine and apoptosis in rat's fast stress model. The aim of this study was to evaluate the effect of DKT on maintenance of microbial diversity in rat's intestine with inflammation. Wister rats were received the fast stress for 5 days. In DKT group, rats were administered with DKT (300 mg/kg/day) during the fast stress (DKT-group). The gut microbiomes were analyzed at before- and after- fast stress, and the effect of DKT for on microbial diversities of the gut were evaluated by the PCR-clone library method targeting the 16 S ribosomal RNA gene. In Control-group, Erysipelotrichaceae increased to 86% in after fast stress, OTU of before-fast stress was 111 and after fast stress was only 9 (changing rate: 58%). The diversity of microbiome was severely decreased. On the other hand, in DKT-group, diversity of microbiome was kept after fast stress (Lachnospiraceae: Ruminococcaceae: Coriobacteriales 54%, 22%, 5%), Operational taxonomic units of before fast stress was 52 and after fast stress was 55 (changing rate: 6%). Family Lachnospiraceae which includes butyrate-producing Clostridia (Clostridium IV and XIVa). DKT prevented the reduction of diversity of microbiome in rat's fast stress model. Our data suggested the new anti-inflammatory mechanism of DKT through gut microbiome.  (日)    [継承]
キーワード (推奨): 1. (英) (日) 英文論文 (読) [継承]
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誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2013年 0月 初日 (平成 25年 0月 初日) [継承]
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DOI (任意): 10.2152/jmi.60.221    (→Scopusで検索) [継承]
PMID (任意): 24190039    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84887006293 [継承]
機関リポジトリ : 106360 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kouzou Yoshikawa, Mitsuo Shimada, Tomomi Kuwahara, Hideki Hirakawa, Nobuhiro Kurita, Horohiko Sato, Toru Utsunomiya, Takashi Iwata, Tomohiko Miyatani, Jun Higashijima, Hideya Kashihara, Chie Takasu, Noriko Matsumoto and Haruyuki Nakayama-Imaohji : Effect of Kampo medicine "Dai-kenchu-to" on microbiome in the intestine of the rats with fast stress., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 221-227, (month)2013.
欧文冊子 ● Kouzou Yoshikawa, Mitsuo Shimada, Tomomi Kuwahara, Hideki Hirakawa, Nobuhiro Kurita, Horohiko Sato, Toru Utsunomiya, Takashi Iwata, Tomohiko Miyatani, Jun Higashijima, Hideya Kashihara, Chie Takasu, Noriko Matsumoto and Haruyuki Nakayama-Imaohji : Effect of Kampo medicine "Dai-kenchu-to" on microbiome in the intestine of the rats with fast stress., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 221-227, (month)2013.

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