| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takahashi Tamaki (日) (読)
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| 2. | (英) Muro Shigeo (日) (読)
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| 3. | (英) Tanabe Naoya (日) (読)
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| 4. | (英) Terada Kunihiko (日) (読)
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| 5. | (英) Kiyokawa Hirofumi (日) (読)
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| 6. | (英) Sato Susumu (日) (読)
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| 7. | (英) Hoshino Yuma (日) (読)
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| 8. | (英) Ogawa Emiko (日) (読)
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| 9. | (英) Uno Kazuko (日) (読)
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| 10. | 成石 浩司
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| 11. | (英) Takashiba Shogo (日) (読)
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| 12. | (英) Mishima Michiaki (日) (読)
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| ○題名 (必須): | □ | (英) Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease. (日)
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| ○要約 (任意): | □ | (英) Normal-IgG titer for periodontitis-related antibody can be an independent predictor of frequent exacerbations. Measuring periodontitis-related antibody titers might be useful to identify patients with susceptibility to frequent exacerbations so that an aggressive prevention strategy can be designed. (日) The numbers of exacerbations and the rate of individuals with frequent exacerbations (at least two per year) were significantly lower in patients with higher IgG titer than those with normal IgG titer (0.8 vs. 1.2 per year, p= 0.045 and 14.3 vs. 38.6%, p= 0.009, respectively). Multivariate logistic regression analysis showed that being normal-IgG titer for periodontitis-related antibody significantly increased the risk of frequent exacerbations (relative risk, 5.27, 95% confidence interval, 1.30-25.7; p = 0.019) after adjusting for other possible confounders, such as a history of exacerbations in the past year, disease severity, COPD medication and smoking status.
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Aged, 80 and over (日) (読)
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| 3. | (英) Antibodies, Bacterial (日) (読)
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| 4. | (英) Cohort Studies (日) (読)
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| 5. | 細胞質分裂 (cytokinesis)
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| 6. | (英) Disease Progression (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Immunoglobulin G (日) (読)
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| 9. | (英) Inflammation Mediators (日) (読)
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| 10. | (英) Logistic Models (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Middle Aged (日) (読)
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| 13. | 歯周病 (periodontitis)
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| 14. | (英) Porphyromonas gingivalis (日) (読)
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| 15. | (英) Prognosis (日) (読)
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| 16. | (英) Prospective Studies (日) (読)
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| 17. | (英) Pulmonary Disease, Chronic Obstructive (日) (読)
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| 18. | (英) Risk Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | e40570 e40570
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| ○年月日 (必須): | □ | 西暦 2012年 7月 11日 (平成 24年 7月 11日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0040570 (→Scopusで検索)
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| ○PMID (任意): | □ | 22792372 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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