『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=280272EID:280272, Map:0, LastModified:2014年12月17日(水) 15:59:54, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 淳一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.板東 美香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学]/[徳島大学.病院.診療科.歯科.歯周病科(第二保存科)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Zou Xianqiong (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.片岡 正俊
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Ross F. Karen (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.永田 俊彦
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Herzberg C. Mark (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9.木戸 淳一 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Mechanism of interleukin-1α transcriptional regulation of S100A9 in a human epidermal keratinocyte cell line  (日)    [継承]
副題 (任意):
要約 (任意): (英) S100A9 is a calcium-binding protein and subunit of antimicrobial calprotectin complex (S100A8/A9). Produced by neutrophils, monocytes/macrophages and keratinocytes, S100A9 expression increases in response to inflammation. For example, IL-1α produced by epithelial cells acts autonomously on the same cells to induce the expression of S100A8/A9 and cellular differentiation. Whereas it is well known that IL-1α and members of the IL-10 family of cytokines upregulate S100A8 and S100A9 in several cell lineages, the pathway and mechanism of IL-1α-dependent transcriptional control of S100A9 in epithelial cells are not established. Modeled using human epidermal keratinocytes (HaCaT cells), IL-1α stimulated the phosphorylation of p38 MAPK and induced S100A9 expression, which was blocked by IL-1 receptor antagonist, RNAi suppression of p38, or a p38 MAPK inhibitor. Transcription of S100A9 in HaCaT cells depended on nucleotides -94 to -53 in the upstream promoter region, based upon the use of deletion constructs and luciferase reporter activity. Within the responsive promoter region, IL-1α increased the binding activity of CCAAT/enhancer binding protein β (C/EBPβ). Mutated C/EBPβ binding sequences or C/EBPβ-specific siRNA inhibited the S100A9 transcriptional response. Hence, IL-1α is strongly suggested to increase S100A9 expression in a human epidermal keratinocyte cell line by signaling through the IL-1 receptor and p38 MAPK, increasing C/EBPβ-dependent transcriptional activity.  (日)    [継承]
キーワード (推奨): 1. (英) Base Sequence (日) (読) [継承]
2. (英) Calgranulin B (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) DNA Primers (日) (読) [継承]
5. (英) Epidermis (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Interleukin-1alpha (日) (読) [継承]
8. (英) Keratinocytes (日) (読) [継承]
9. (英) Polymerase Chain Reaction (日) (読) [継承]
10. (英) RNA Interference (日) (読) [継承]
11. (英) Transcription, Genetic (日) (読) [継承]
12. (英) p38 Mitogen-Activated Protein Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ([Elsevier Science])
(pISSN: 1874-9399)

ISSN (任意): 1874-9399
ISSN: 1874-9399 (pISSN: 1874-9399, eISSN: 1876-4320)
Title: Biochimica et biophysica acta. Gene regulatory mechanisms
Title(ISO): Biochim Biophys Acta Gene Regul Mech
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1829 [継承]
(必須): 9 [継承]
(必須): 954 962 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 4月 3日 (平成 25年 4月 3日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbagrm.2013.03.010    (→Scopusで検索) [継承]
PMID (任意): 23563247    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000322414600007 [継承]
Scopus (任意): 2-s2.0-84880346974 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.bbagrm.2013.03.010  (日)    [継承]
2.(英) Article.ELocationID: S1874-9399(13)00055-2  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
6.(英) OtherID: NIHMS464927  (日)    [継承]
7.(英) OtherID: PMC3719387  (日)    [継承]
8.(英) KeywordList.Keyword: C/EBPβ  (日)    [継承]
9.(英) KeywordList.Keyword: ERK  (日)    [継承]
10.(英) KeywordList.Keyword: IL-1 receptor  (日)    [継承]
11.(英) KeywordList.Keyword: IL-1R1  (日)    [継承]
12.(英) KeywordList.Keyword: IL-1α  (日)    [継承]
13.(英) KeywordList.Keyword: JNK  (日)    [継承]
14.(英) KeywordList.Keyword: Keratinocytes  (日)    [継承]
15.(英) KeywordList.Keyword: S100A9  (日)    [継承]
16.(英) KeywordList.Keyword: TLR5  (日)    [継承]
17.(英) KeywordList.Keyword: Toll-like receptor 5  (日)    [継承]
18.(英) KeywordList.Keyword: c-JUN N-terminal kinase  (日)    [継承]
19.(英) KeywordList.Keyword: extracellular-regulated kinase  (日)    [継承]
20.(英) KeywordList.Keyword: p38  (日)    [継承]
21.(英) KeywordList.Keyword: p38 kinase  (日)    [継承]
22.(英) KeywordList.Keyword: siRNA  (日)    [継承]
23.(英) KeywordList.Keyword: small interfering RNA  (日)    [継承]

標準的な表示

和文冊子 ● Mika Bandou, Xianqiong Zou, Yuka Hiroshima, Masatoshi Kataoka, Karen F. Ross, Yasuo Shinohara, Toshihiko Nagata, Mark C. Herzberg and Jun-ichi Kido : Mechanism of interleukin-1α transcriptional regulation of S100A9 in a human epidermal keratinocyte cell line, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Vol.1829, No.9, 954-962, 2013.
欧文冊子 ● Mika Bandou, Xianqiong Zou, Yuka Hiroshima, Masatoshi Kataoka, Karen F. Ross, Yasuo Shinohara, Toshihiko Nagata, Mark C. Herzberg and Jun-ichi Kido : Mechanism of interleukin-1α transcriptional regulation of S100A9 in a human epidermal keratinocyte cell line, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Vol.1829, No.9, 954-962, 2013.

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