| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kurimoto Shin-ichiro (日) (読)
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| 2. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| 3. | (英) Ahmed Ali Fakhruddin (日) (読)
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| 4. | 柏田 良樹
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| ○題名 (必須): | □ | (英) Triterpenoids from the fruits of Azadirachta indica (Meliaceae). (日)
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| ○要約 (任意): | □ | (英) Four new triterpenoids, indicalilacols A-D (1-4), were isolated from the MeOH extract of the fruits of Azadirachta indica, including a new 19(109)abeo-tirucallane derivative, two new tirucallane-type triterpenoids, and a new euphane-type triterpenoid, along with three known tirucallane-type triterpenoids. Their structures were elucidated on the basis of spectroscopic analyses. The absolute configuration of 2 was elucidated by the chemical conversion of 2 into 21-oxo-melianodiol 24,25-acetonide. Compounds 2, 6-8 exhibited moderate cytotoxicity against three human cancer cell lines, including multidrug-resistant (MDR) cancer cells (KB-C2). Although compound 5 was not cytotoxic against any of the tested cancer cell lines, 5 showed cytotoxicity against KB-C2 cells in the presence of 2.5 M colchicine, suggesting that 5 might have an MDR-reversal effect. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Fitoterapia ([Elsevier])
(pISSN: 0367-326X, eISSN: 1873-6971)
| ○ISSN (任意): | □ | 1873-6971
ISSN: 0367-326X
(pISSN: 0367-326X, eISSN: 1873-6971) Title: FitoterapiaTitle(ISO): FitoterapiaPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
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| ○巻 (必須): | □ | 92
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| ○号 (必須): |
| ○頁 (必須): | □ | 200 205
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 1月 初日 (平成 26年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.fitote.2013.11.004 (→Scopusで検索)
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| ○PMID (任意): | □ | 24239747 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000331420300025
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| ○Scopus (任意): | □ | 2-s2.0-84890056124
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.fitote.2013.11.004 (日)
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| 2. | (英) Article.ELocationID: S0367-326X(13)00299-2 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Azadirachta indica (日)
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| 5. | (英) KeywordList.Keyword: Cytotoxicity (日)
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| 6. | (英) KeywordList.Keyword: Meliaceae (日)
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| 7. | (英) KeywordList.Keyword: Triterpenoid (日)
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