『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=279308EID:279308, Map:0, LastModified:2017年11月27日(月) 18:33:52, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2. (英) Shindo Satoru (日) 進藤 智 (読) しんどう さとる
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3.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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4.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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5.松尾 敬志
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題名 (必須): (英) IL-6 trans-signaling enhances CCL20 production from IL-1-stimulated human periodontal ligament cells.  (日)    [継承]
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要約 (任意): (英) CC chemokine ligand 20 (CCL20) plays a central role in the recruitment of CCR6-expressing cells, including Th17 cells which are related to bone resorption in periodontal lesions and thus in the development of periodontal disease. IL-6 is an important cytokine that is associated with the pathogenesis of periodontitis. However, the effect of IL-6 on CCL20 production is uncertain. The aim of this study was to examine whether IL-6 could modify CCL20 expression in human periodontal ligament cells (HPDLCs). HPDLCs expressed gp130 but did not express IL-6R on the surface of HPDLCs. So, IL-6 trans-signaling is important to recognize IL-6 by HPDLCs. IL-6/sIL-6R stimulation enhanced CCL20 production in IL-1-stimulated HPDLCs. IL-6 produced from IL-1-stimulated HPDLCs with sIL-6R could increase CCL20 production in HPDLCs with sIL-6R. Signal transducer and activator of transcription (STAT)3 activation was related to CCL20 production in IL-1 and IL-6/sIL-6R-stimulated HPDLCs. Our data suggests that HPDLCs, in response to IL-6, sIL-6R, and IL-1, may shift chemokine production to that favoring CCR6-expressing cells recruitment in periodontal lesions.  (日)    [継承]
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誌名 (必須): Inflammation ([Springer-Verlag])
(pISSN: 0360-3997, eISSN: 1573-2576)

ISSN (任意): 1573-2576
ISSN: 0360-3997 (pISSN: 0360-3997, eISSN: 1573-2576)
Title: Inflammation
Title(ISO): Inflammation
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2014年 4月 初日 (平成 26年 4月 初日) [継承]
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DOI (任意): 10.1007/s10753-013-9750-8    (→Scopusで検索) [継承]
PMID (任意): 24081898    (→Scopusで検索) [継承]
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WOS (任意): 000332715000011 [継承]
Scopus (任意): 2-s2.0-84896326562 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Satoru Shindo, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo : IL-6 trans-signaling enhances CCL20 production from IL-1-stimulated human periodontal ligament cells., Inflammation, Vol.37, No.2, 381-386, 2014.
欧文冊子 ● Yoshitaka Hosokawa, Satoru Shindo, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo : IL-6 trans-signaling enhances CCL20 production from IL-1-stimulated human periodontal ligament cells., Inflammation, Vol.37, No.2, 381-386, 2014.

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