『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=278996)

EID=278996EID:278996, Map:0, LastModified:2014年12月9日(火) 12:00:21, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宮本 洋二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.内田 大亮
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.栗林 伸行
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学籍番号 (推奨):
[継承]
3.大江 剛 ([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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学籍番号 (推奨):
[継承]
4.玉谷 哲也
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学籍番号 (推奨):
[継承]
5.永井 宏和
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学籍番号 (推奨):
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6.宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Expression and function of CXCR4 in human salivary gland cancers  (日)    [継承]
副題 (任意):
要約 (任意): (英) Salivary gland cancers (SGCs) frequently metastasize to cervical lymph nodes and distant organs. Currently, the mechanisms responsible for the metastatic behavior of SGC cells are not fully understood. We previously demonstrated that the stromal cell-derived factor-1 (SDF-1; also known as CXCL12)/CXCR4 system is involved in the establishment of metastasis in oral squamous cell carcinoma. In the present study, we investigated the role of CXCR4 in the metastatic behavior of SGCs. We examined the expression of CXCR4 mRNA and protein in human SGC cell lines by quantitative RT-PCR and western blotting, respectively. The expression of CXCR4 mRNA and protein were frequently upregulated in 5 out of 6 SGC cell lines. Functional CXCR4 expression was demonstrated by the ability of these SGC cell lines to migrate toward an SDF-1 gradient. SDF-1 rapidly activated extracellular signal-regulated kinase (ERK)1/2 in SGC cell lines. Immunohistochemical analysis revealed that CXCR4 protein expression was detected in either the nucleus or cytoplasm of cancer cells in 16 out of 20 tissues of adenoid cystic carcinoma (ACC) and in 4 out of 6 tissues of mucoepidermoid carcinoma, which are representative of SGC. Furthermore, ACC cell lines exhibited dramatic metastasis to the lung following intravenous inoculation, whereas AMD3100, a CXCR4 antagonist, significantly inhibited lung metastasis of the cells, ameliorated body weight loss and improved the survival rate of tumor-bearing nude mice. These results indicate that CXCR4 expression contributes to the metastatic potential of SGCs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Adhesion (日) (読) [継承]
5. (英) Cell Movement (日) (読) [継承]
6. (英) Chemokine CXCL12 (日) (読) [継承]
7. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
8. (英) Flow Cytometry (日) (読) [継承]
9. (英) Heterocyclic Compounds (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Immunoenzyme Techniques (日) (読) [継承]
12. (英) Lung Neoplasms (日) (読) [継承]
13. (英) Lymphatic Metastasis (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred BALB C (日) (読) [継承]
16. (英) Mice, Nude (日) (読) [継承]
17. (英) Mitogen-Activated Protein Kinase 3 (日) (読) [継承]
18. (英) RNA, Messenger (日) (読) [継承]
19. (英) Real-Time Polymerase Chain Reaction (日) (読) [継承]
20. (英) Receptors, CXCR4 (日) (読) [継承]
21. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
22. (英) Salivary Gland Neoplasms (日) (読) [継承]
23. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical & Experimental Metastasis (Metastasis Research Society)
(pISSN: 0262-0898, eISSN: 1573-7276)

ISSN (任意): 1573-7276
ISSN: 0262-0898 (pISSN: 0262-0898, eISSN: 1573-7276)
Title: Clinical & experimental metastasis
Title(ISO): Clin. Exp. Metastasis
Supplier: Kluwer Online
Publisher: Springer Netherlands
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 30 [継承]
(必須): 2 [継承]
(必須): 133 142 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 2月 初日 (平成 25年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s10585-012-9518-9    (→Scopusで検索) [継承]
PMID (任意): 22847686    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000314271600002 [継承]
Scopus (任意): 2-s2.0-84875066432 [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1007/s10585-012-9518-9  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Nobuyuki Kuribayashi, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Expression and function of CXCR4 in human salivary gland cancers, Clinical & Experimental Metastasis, Vol.30, No.2, 133-142, 2013.
欧文冊子 ● Daisuke Uchida, Nobuyuki Kuribayashi, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Expression and function of CXCR4 in human salivary gland cancers, Clinical & Experimental Metastasis, Vol.30, No.2, 133-142, 2013.

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