『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=278994)

EID=278994EID:278994, Map:0, LastModified:2017年12月7日(木) 16:41:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宮本 洋二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.永井 宏和
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2.小林 真左子
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3.大江 剛 ([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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4. (英) Hara Kanae (日) 原 香苗 (読)
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5.髙丸 菜都美
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6.内田 大亮
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7.玉谷 哲也
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8.藤澤 健司
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9.宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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題名 (必須): (英) Antitumour effect of valproic acid against salivary gland cancer in vitro and in vivo  (日)    [継承]
副題 (任意):
要約 (任意): (英) Salivary gland cancer (SGC) has a comparatively poor prognosis and is prone to frequent recurrence and metastases. Therefore, the development of more effective chemotherapy against SGC is desirable. The aim of the present study was to investigate the antitumour effects of valproic acid (VPA) against SGC in vitro and in vivo. Two human SGC cell lines (HSY and HSG cells) were used in the present study. The effects of VPA on the proliferation of SGC cells in vitro were assessed by MTT assay. Cancer cells treated with VPA were subjected to cell cycle analysis by flow cytometry. In addition, the expression levels of p21 and p27 were examined by real-time RT-PCR to identify the mechanisms of the antitumour effect of VPA on SGC. The effects of VPA on cancer growth in vivo were evaluated in a xenograft model. VPA inhibited the proliferation of SGC cells in a dose-dependent manner in vitro. Degenerated cancer cells were observed at high concentrations of VPA. In the cell cycle analysis, VPA induced cell-growth inhibition and G1 arrest of cell cycle progression in both cancer cell lines in a time- and dose-dependent manner. VPA markedly upregulated the mRNA expression levels of both p21 and p27 in both SGC cell lines in a time-dependent manner. In the xenograft model experiment, VPA treatment markedly inhibited the growth of salivary gland tumours when compared with the growth of the untreated controls. VPA may be a valuable drug in the development of better therapeutic regimens for SGC.  (日)    [継承]
キーワード (推奨): 1. (英) Adenocarcinoma (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antineoplastic Agents (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Cell Survival (日) (読) [継承]
6. (英) Cyclin-Dependent Kinase Inhibitor p21 (日) (読) [継承]
7. (英) Cyclin-Dependent Kinase Inhibitor p27 (日) (読) [継承]
8. (英) Gene Expression (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Inbred BALB C (日) (読) [継承]
12. (英) Mice, Nude (日) (読) [継承]
13. (英) Salivary Gland Neoplasms (日) (読) [継承]
14. (英) Valproic Acid (日) (読) [継承]
15. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)

ISSN (任意): 1791-2431
ISSN: 1021-335X (pISSN: 1021-335X, eISSN: 1791-2431)
Title: Oncology reports
Title(ISO): Oncol. Rep.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 31 [継承]
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(必須): 1453 1458 [継承]
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年月日 (必須): 西暦 2014年 3月 1日 (平成 26年 3月 1日) [継承]
URL (任意):
DOI (任意): 10.3892/or.2013.2959    (→Scopusで検索) [継承]
PMID (任意): 24398788    (→Scopusで検索) [継承]
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WOS (任意): 000332693700055 [継承]
Scopus (任意): 2-s2.0-84896709497 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3892/or.2013.2959  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hirokazu Nagai, Masako Fujioka-Kobayashi, Go Ohe, Kanae Hara, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : Antitumour effect of valproic acid against salivary gland cancer in vitro and in vivo, Oncology Reports, Vol.31, No.3, 1453-1458, 2014.
欧文冊子 ● Hirokazu Nagai, Masako Fujioka-Kobayashi, Go Ohe, Kanae Hara, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : Antitumour effect of valproic acid against salivary gland cancer in vitro and in vivo, Oncology Reports, Vol.31, No.3, 1453-1458, 2014.

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