『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=278952EID:278952, Map:0, LastModified:2022年5月5日(木) 21:05:20, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[玉井 伸岳], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Kitayama Hiroki (日) (読)
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2. (英) Takechi Yuki (日) (読)
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3.玉井 伸岳 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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4.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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5. (英) Yomota Chikako (日) (読)
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6.斎藤 博幸
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題名 (必須): (英) Thermotropic phase behavior of hydrogenated soybean phosphatidylcholine-cholesterol binary liposome membrane.  (日)    [継承]
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要約 (任意): (英) By combination of differential scanning calorimetry (DSC) and fluorescence spectroscopy of 6-propionyl-2-(dimethylamino)naphthalene (Prodan), we elucidated the thermotropic phase behavior of hydrogenated soybean phosphatidylcholine (HSPC)-cholesterol binary liposome membrane which has similar lipid composition to Doxil®, the widely used liposome product in treatment of various tumors. We found that the characteristic points at cholesterol mole fraction (Xch)=0.023 and 0.077 correspond to the hexagonal lattice, in which cholesterol molecules are considered to be regularly distributed in all regions of HSPC lipid bilayer with 1 : 42 and 1 : 12 units, respectively, as static averaged structures. Apparent endothermic peak disappeared at Xch=0.40 in the DSC thermograms, indicating the existence of single liquid ordered phase at Xch>0.40. In addition, fluorescence measurements of Prodan and its lauroyl derivative in poly(ethylene glycol) (PEG)-modified liposomes indicated that PEG modification has a negligible effect on the phase behavior of HSPC-cholesterol binary liposome membrane. These results may provide useful information in developing novel liposome products whose stability and encapsulated drug release are controlled.  (日) By combination of differential scanning calorimetry (DSC) and fluorescence spectroscopy of 6-propionyl-2-(dimethylamino)naphthalene (Prodan), we elucidated the thermotropic phase behavior of hydrogenated soybean phosphatidylcholine (HSPC)-cholesterol binary liposome membrane which has similar lipid composition to Doxil®, the widely used liposome product in treatment of various tumors. We found that the characteristic points at cholesterol mole fraction (Xch)=0.023 and 0.077 correspond to the hexagonal lattice, in which cholesterol molecules are considered to be regularly distributed in all regions of HSPC lipid bilayer with 1 : 42 and 1 : 12 units, respectively, as static averaged structures. Apparent endothermic peak disappeared at Xch=0.40 in the DSC thermograms, indicating the existence of single liquid ordered phase at Xch>0.40. In addition, fluorescence measurements of Prodan and its lauroyl derivative in poly(ethylene glycol) (PEG)-modified liposomes indicated that PEG modification has a negligible effect on the phase behavior of HSPC-cholesterol binary liposome membrane. These results may provide useful information in developing novel liposome products whose stability and encapsulated drug release are controlled.   [継承]
キーワード (推奨): 1. (英) liposome (日) (読) [継承]
2. (英) cholesterol (日) (読) [継承]
3. (英) phase diagram (日) (読) [継承]
4. (英) differential scanning calorimetry (日) (読) [継承]
5. (英) Prodan (日) (読) [継承]
発行所 (推奨): (英) The Pharmaceutical Society of Japan (日) (読) [継承]
誌名 (必須): Chemical & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0009-2363, eISSN: 1347-5223)

ISSN (任意): 1347-5223
ISSN: 0009-2363 (pISSN: 0009-2363, eISSN: 1347-5223)
Title: Chemical & pharmaceutical bulletin
Title(ISO): Chem Pharm Bull (Tokyo)
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
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年月日 (必須): 西暦 2014年 0月 初日 (平成 26年 0月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/130003381805/ [継承]
DOI (任意): 10.1248/cpb.c13-00587    (→Scopusで検索) [継承]
PMID (任意): 24390493    (→Scopusで検索) [継承]
CRID (任意): 1390282679153790464 [継承]
NAID : 130003381805 [継承]
WOS (任意): 000329002300008 [継承]
Scopus (任意): 2-s2.0-84892158447 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroki Kitayama, Yuki Takechi, Nobutake Tamai, Hitoshi Matsuki, Chikako Yomota and Hiroyuki Saito : Thermotropic phase behavior of hydrogenated soybean phosphatidylcholine-cholesterol binary liposome membrane., Chemical & Pharmaceutical Bulletin, Vol.62, No.1, 58-63, 2014.
欧文冊子 ● Hiroki Kitayama, Yuki Takechi, Nobutake Tamai, Hitoshi Matsuki, Chikako Yomota and Hiroyuki Saito : Thermotropic phase behavior of hydrogenated soybean phosphatidylcholine-cholesterol binary liposome membrane., Chemical & Pharmaceutical Bulletin, Vol.62, No.1, 58-63, 2014.

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