『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=278785)

EID=278785EID:278785, Map:0, LastModified:2015年12月2日(水) 13:48:50, Operator:[山中 絹代], Avail:TRUE, Censor:0, Owner:[松久 宗英], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yoshii Hidenori (日) (読)
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2. (英) Onuma Tomio (日) (読)
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3. (英) Yamazaki Tsutomu (日) (読)
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4. (英) Watada Hirotaka (日) (読)
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5.松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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6. (英) Matsumoto Masayasu (日) (読)
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7. (英) Kitagawa Kazuo (日) (読)
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8. (英) Kitakaze Masafumi (日) (読)
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9. (英) Yamasaki Yoshimitsu (日) (読)
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10. (英) Kawamori Ryuzo (日) (読)
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題名 (必須): (英) Effects of Pioglitazone on Macrovascular Events in Patients with Type 2 Diabetes Mellitus at High Risk of Stroke: The PROFIT-J Study.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Aim: The present study evaluated the effects of pioglitazone treatment on the incidence of primary cardiovascular events in Japanese subjects with type 2 diabetes mellitus at high risk of stroke. Methods: A prospective, multicenter, randomized, open label, comparative study was conducted among diabetic patients recruited from 50 medical institutions nationwide. A total of 522 patients with hypertension and/or dyslipidemia who had one or more silent cerebral infarcts, advanced carotid atherosclerosis or microalbuminuria at baseline were randomly treated with (n=254) or without pioglitazone (n=268) and observed for a medium of 672 days. The hypertension and dyslipidemia were concurrently treated according to the respective treatment guidelines. The primary outcome was the time to the first occurrence of a composite of all-cause death, nonfatal cerebral infarction and nonfatal myocardial infarction. Results: Treatment with pioglitazone resulted in significant reductions in the levels of HbA1c, diastolic blood pressure and LDL-cholesterol and a significant increase in the levels of HDL-cholesterol. The pioglitazone non-users exhibited a significant reduction in the LDL-cholesterol levels alone. Primary events were registered during the study period in nine patients in the pioglitazone group and 10 patients in the non-pioglitazone group. The difference in the cumulative incidence of the primary outcome was not significant between the two groups(1.8% per year). Conclusions: Pioglitazone therapy produces immediate and effective improvements in glycemic control, diastolic blood pressure and lipid profiles. While this study was too underpowered to determine the effects of pioglitazone on the incidence of cardiovascular events, the results indicated that two years of pioglitazone treatment did not produce any statistically significant reductions in the rate of primary cardiovascular events.  (日)    [継承]
キーワード (推奨): 1. (英) Pioglitazone (日) (読) [継承]
2. (英) Primary prevention (日) (読) [継承]
3. (英) Mortality-macrovascular events (日) (読) [継承]
4. (英) Diabetes mellitus (日) (読) [継承]
発行所 (推奨): (英) Japan Atherosclerosis Society (日) (読) [継承]
誌名 (必須): Journal of Atherosclerosis and Thrombosis (日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)

ISSN (任意): 1880-3873
ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873)
Title: Journal of atherosclerosis and thrombosis
Title(ISO): J Atheroscler Thromb
Supplier: 一般社団法人 日本動脈硬化学会
Publisher: Japan Atherosclerosis Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 21 [継承]
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(必須): 563 573 [継承]
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年月日 (必須): 西暦 2014年 1月 29日 (平成 26年 1月 29日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/130004444748/ [継承]
DOI (任意): 10.5551/jat.21626    (→Scopusで検索) [継承]
PMID (任意): 24477028    (→Scopusで検索) [継承]
NAID (任意): 130004444748 [継承]
WOS (任意): 000342070500005 [継承]
Scopus (任意): 2-s2.0-84903184764 [継承]
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備考 (任意): 1.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Hidenori Yoshii, Tomio Onuma, Tsutomu Yamazaki, Hirotaka Watada, Munehide Matsuhisa, Masayasu Matsumoto, Kazuo Kitagawa, Masafumi Kitakaze, Yoshimitsu Yamasaki and Ryuzo Kawamori : Effects of Pioglitazone on Macrovascular Events in Patients with Type 2 Diabetes Mellitus at High Risk of Stroke: The PROFIT-J Study., Journal of Atherosclerosis and Thrombosis, Vol.21, No.6, 563-573, 2014.
欧文冊子 ● Hidenori Yoshii, Tomio Onuma, Tsutomu Yamazaki, Hirotaka Watada, Munehide Matsuhisa, Masayasu Matsumoto, Kazuo Kitagawa, Masafumi Kitakaze, Yoshimitsu Yamasaki and Ryuzo Kawamori : Effects of Pioglitazone on Macrovascular Events in Patients with Type 2 Diabetes Mellitus at High Risk of Stroke: The PROFIT-J Study., Journal of Atherosclerosis and Thrombosis, Vol.21, No.6, 563-573, 2014.

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