『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.木内 美瑞穂
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2.粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).糖尿病・代謝疾患治療医学])
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3.藤中 雄一
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4.吉田 守美子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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5. (英) Ooguro Yukari (日) (読)
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6. (英) Kurahashi Kiyoe (日) (読)
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7.近藤 剛史
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8. (英) Aki Nanako (日) (読)
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9.黒田 暁生 ([徳島大学.先端酵素学研究所.糖尿病臨床・研究開発領域])
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10.遠藤 逸朗 ([徳島大学.大学院医歯薬学研究部.保健科学域.保健科学部門.医用検査学系.生体機能解析学])
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11.松久 宗英 ([徳島大学.先端酵素学研究所.糖尿病臨床・研究開発領域]/徳島大学病院アンチエイジングセンター センター長(併任))
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12.松本 俊夫
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題名 (必須): (英) Diabetic conditions differentially affect the endothelial function, arterial stiffness and carotid atherosclerosis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Aim: The levels of fasting and postprandial plasma glucose, HbA1c and other risk factors for atherosclerosis have distinct effects in patients with and those without diabetes mellitus. The aim of this study was to determine the impact of diabetic surrogate markers on the endothelial function, arterial stiffness and carotid atherosclerosis in individuals with and without diabetes. Methods: A total of 320 Japanese subjects(mean age: 61.2±12.1 years) were recruited in this study. Demographic, clinical and laboratory parameters, including 75 g OGTT(155 subjects) results, were examined. The endothelial function was evaluated according to the flow-mediated vasodilation of the brachial artery(%FMD). In addition, arterial stiffness was evaluated according to the brachial-ankle pulse wave velocity(baPWV), and carotid atherosclerotic changes were estimated according to the maximum intima-media thickness(max-IMT) and resistive index of the common carotid artery(CCA-RI). A multiple regression analysis was performed to identify independent determinants of these vascular surrogate markers. Results: None of the glucose-related parameters were associated with the %FMD. In contrast, the presence of T2DM, the HbA1c level and an increased plasma glucose level at 60 minutes during 75 g OGTT were associated with an increased baPWV. The HbA1c level was also correlated with an increased max-IMT. The fasting plasma glucose(FPG) level and the presence of T2DM correlated with an increased CCA-RI. In the subjects with T2DM, the protective effects of high-density lipoprotein cholesterol(HDL-C) on the %FMD and baPWV were abolished. Conclusions: Various glucose metabolism parameters have different effects the degree of arterial stiffness and presence of carotid atherosclerosis, but not the endothelial function, suggesting that pharmacological intervention has the potential to preserve the endothelial function in diabetic individuals. In addition, the presence of T2DM blunts the vascular protective effects of HDL-C on the endothelial function and progression of arterial stiffness.  (日)    [継承]
キーワード (推奨): 1. (英) Type 2 diabetes (日) (読) [継承]
2. (英) Endothelial function (日) (読) [継承]
3. (英) Arterial stiffness (日) (読) [継承]
4. (英) Carotid atherosclerosis (日) (読) [継承]
発行所 (推奨): (英) Japan Atherosclerosis Society (日) (読) [継承]
誌名 (必須): Journal of Atherosclerosis and Thrombosis (日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)

ISSN (任意): 1880-3873
ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873)
Title: Journal of atherosclerosis and thrombosis
Title(ISO): J. Atheroscler. Thromb.
Supplier: 一般社団法人 日本動脈硬化学会
Publisher: Japan Atherosclerosis Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 21 [継承]
(必須): 5 [継承]
(必須): 486 500 [継承]
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年月日 (必須): 西暦 2014年 1月 8日 (平成 26年 1月 8日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/130004444734/ [継承]
DOI (任意): 10.5551/jat.20834    (→Scopusで検索) [継承]
PMID (任意): 24401746    (→Scopusで検索) [継承]
NAID (任意): 130004444734 [継承]
WOS (任意): 000342070300012 [継承]
Scopus (任意): 2-s2.0-84901494272 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mizuho Kinouchi, Ken-ichi Aihara, Yuichi Fujinaka, Sumiko Yoshida, Yukari Ooguro, Kiyoe Kurahashi, Takeshi Kondo, Nanako Aki, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa and Toshio Matsumoto : Diabetic conditions differentially affect the endothelial function, arterial stiffness and carotid atherosclerosis., Journal of Atherosclerosis and Thrombosis, Vol.21, No.5, 486-500, 2014.
欧文冊子 ● Mizuho Kinouchi, Ken-ichi Aihara, Yuichi Fujinaka, Sumiko Yoshida, Yukari Ooguro, Kiyoe Kurahashi, Takeshi Kondo, Nanako Aki, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa and Toshio Matsumoto : Diabetic conditions differentially affect the endothelial function, arterial stiffness and carotid atherosclerosis., Journal of Atherosclerosis and Thrombosis, Vol.21, No.5, 486-500, 2014.

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