『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=278536EID:278536, Map:0, LastModified:2017年11月29日(水) 17:45:05, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐藤 陽一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Teruaki Iwamoto (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.新家 利一
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学籍番号 (推奨):
[継承]
4. (英) Shiari Nozawa (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Miki Yoshiike (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Eitetsue Koh (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Jiro Kanaya (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Mikio Namiki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Kiyomi Matsumiya (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Akira Tsujimura (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Kiyoshi Komatsu (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
12. (英) Naoki Itoh (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
13. (英) Jiro Eguchi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
14.山内 あい子
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学籍番号 (推奨):
[継承]
15.中堀 豊
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Y chromosome gr/gr subdeletion is associated with lower semen quality in young men from the general Japanese population but not in fertile Japanese men  (日)    [継承]
副題 (任意):
要約 (任意): (英) Several case-control studies have investigated whether Y chromosome haplogroups or deletions are associated with spermatogenic failure. However, the relationships between Y chromosome haplogroups or deletions and semen quality in general population have not been elucidated. In this study, we assessed relationships between Y chromosome haplogroups or deletions and semen parameters in 791 fertile Japanese men and 1221 young men from the general Japanese population. We found that the haplogroup D2 (M55 lineage) was significantly associated with lower semen parameters, especially total motile sperm count (P = 0.00051, beta = -0.097), in men from the general population but not in fertile men. In addition, we found that the gr/gr subdeletion was associated with semen quality and in particular, strongly associated with decreased sperm motility (P = 0.00041, beta = -3.14) and total motile sperm count (P = 0.00031, beta = -0.099) in men from the general population but not in fertile men. The combined analysis of fertile Japanese men and men from the general Japanese population showed that the haplogroup D2 (M55 lineage) and the gr/gr subdeletion were strongly associated with reduced sperm motility (P = 0.00056, beta = -2.71, and P = 7.7 × 10(-5), beta = -3.05, respectively) and that haplogroup O2b1 was strongly associated with elevated sperm motility (P = 0.00089, beta = 2.94). These observations add further support for the view that the gr/gr subdeletion diminishes sperm motility that consequently may result in male infertility.  (日)    [継承]
キーワード (推奨): 1. (英) Adolescent (日) (読) [継承]
2. (英) Adult (日) (読) [継承]
3. (英) Asian Continental Ancestry Group (日) (読) [継承]
4. (英) Chromosome Deletion (日) (読) [継承]
5. (英) Chromosomes, Human, Y (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Fertility (日) (読) [継承]
8. (英) Haplotypes (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Infertility, Male (日) (読) [継承]
11. (英) Japan (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Pregnancy (日) (読) [継承]
15. (英) Prevalence (日) (読) [継承]
16. (英) Semen Analysis (日) (読) [継承]
17. (英) Spermatozoa (日) (読) [継承]
18. (英) Young Adult (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biology of Reproduction (The Society for the Study of Reproduction)
(pISSN: 0006-3363, eISSN: 1529-7268)

ISSN (任意): 1529-7268
ISSN: 0006-3363 (pISSN: 0006-3363, eISSN: 1529-7268)
Title: Biology of reproduction
Title(ISO): Biol Reprod
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 90 [継承]
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都市 (任意):
年月日 (必須): 西暦 2014年 6月 初日 (平成 26年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1095/biolreprod.114.118810    (→Scopusで検索) [継承]
PMID (任意): 24759788    (→Scopusで検索) [継承]
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WOS (任意): 000337674200001 [継承]
Scopus (任意): 2-s2.0-84903756731 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1095/biolreprod.114.118810  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Meta-Analysis  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: Japanese men  (日)    [継承]
6.(英) KeywordList.Keyword: Y chromosome  (日)    [継承]
7.(英) KeywordList.Keyword: fertility  (日)    [継承]
8.(英) KeywordList.Keyword: genetics  (日)    [継承]
9.(英) KeywordList.Keyword: gr/gr subdeletion  (日)    [継承]
10.(英) KeywordList.Keyword: male infertility  (日)    [継承]
11.(英) KeywordList.Keyword: semen quality  (日)    [継承]
12.(英) KeywordList.Keyword: sperm  (日)    [継承]

標準的な表示

和文冊子 ● Youichi Sato, Iwamoto Teruaki, Toshikatsu Shinka, Nozawa Shiari, Yoshiike Miki, Koh Eitetsue, Kanaya Jiro, Namiki Mikio, Matsumiya Kiyomi, Tsujimura Akira, Komatsu Kiyoshi, Itoh Naoki, Eguchi Jiro, Aiko Yamauchi and Yutaka Nakahori : Y chromosome gr/gr subdeletion is associated with lower semen quality in young men from the general Japanese population but not in fertile Japanese men, Biology of Reproduction, Vol.90, No.6, 116, 2014.
欧文冊子 ● Youichi Sato, Iwamoto Teruaki, Toshikatsu Shinka, Nozawa Shiari, Yoshiike Miki, Koh Eitetsue, Kanaya Jiro, Namiki Mikio, Matsumiya Kiyomi, Tsujimura Akira, Komatsu Kiyoshi, Itoh Naoki, Eguchi Jiro, Aiko Yamauchi and Yutaka Nakahori : Y chromosome gr/gr subdeletion is associated with lower semen quality in young men from the general Japanese population but not in fertile Japanese men, Biology of Reproduction, Vol.90, No.6, 116, 2014.

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