『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=278356EID:278356, Map:0, LastModified:2016年3月25日(金) 15:37:28, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[立花 誠], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Thomas L R (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Miyashita H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Cobb R M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Pierce S (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.立花 誠
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hobeika E (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Reth M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Shinkai Y (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Oltz E M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Functional analysis of histone methyltransferase G9a in B and T lymphocytes  (日)    [継承]
副題 (任意):
要約 (任意): (英) Lymphocyte development is controlled by dynamic repression and activation of gene expression. These developmental programs include the ordered, tissue-specific assembly of Ag receptor genes by V(D)J recombination. Changes in gene expression and the targeting of V(D)J recombination are largely controlled by patterns of epigenetic modifications imprinted on histones and DNA, which alter chromatin accessibility to nuclear factors. An important component of this epigenetic code is methylation of histone H3 at lysine 9 (H3K9me), which is catalyzed by histone methyltransferases and generally leads to gene repression. However, the function and genetic targets of H3K9 methyltransferases during lymphocyte development remain unknown. To elucidate the in vivo function of H3K9me, we generated mice lacking G9a, a major H3K9 histone methyltransferase, in lymphocytes. Surprisingly, lymphocyte development is unperturbed in G9a-deficient mice despite a significant loss of H3K9me2 in precursor B cells. G9a deficiency is manifest as modest defects in the proliferative capacity of mature B cells and their differentiation into plasma cells following stimulation with LPS and IL-4. Precursor lymphocytes from the mutant mice retain tissue- and stage-specific control over V(D)J recombination. However, G9a deficiency results in reduced usage of Iglambda L chains and a corresponding inhibition of Iglambda gene assembly in bone marrow precursors. These findings indicate that the H3K9me2 epigenetic mark affects a highly restricted set of processes during lymphocyte development and activation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibody Formation (日) (読) [継承]
3. (英) B-Lymphocytes (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Enzyme Activation (日) (読) [継承]
7. (英) Histone-Lysine N-Methyltransferase (日) (読) [継承]
8. (英) Immunoglobulin lambda-Chains (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Knockout (日) (読) [継承]
11. (英) Organ Specificity (日) (読) [継承]
12. (英) T-Lymphocytes (日) (読) [継承]
13. (英) VDJ Recombinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 181 [継承]
(必須): 1 [継承]
(必須): 485 493 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 7月 1日 (平成 20年 7月 1日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.181.1.485    (→Scopusで検索) [継承]
PMID (任意): 18566414    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000257404900054 [継承]
Scopus (任意): 2-s2.0-47949091985 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: NIHMS58992  (日)    [継承]
5.(英) OtherID: PMC2497432  (日)    [継承]

標準的な表示

和文冊子 ● R L Thomas, H Miyashita, M R Cobb, S Pierce, Makoto Tachibana, E Hobeika, M Reth, Y Shinkai and M E Oltz : Functional analysis of histone methyltransferase G9a in B and T lymphocytes, The Journal of Immunology, Vol.181, No.1, 485-493, 2008.
欧文冊子 ● R L Thomas, H Miyashita, M R Cobb, S Pierce, Makoto Tachibana, E Hobeika, M Reth, Y Shinkai and M E Oltz : Functional analysis of histone methyltransferase G9a in B and T lymphocytes, The Journal of Immunology, Vol.181, No.1, 485-493, 2008.

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