『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=278107)

EID=278107EID:278107, Map:0, LastModified:2017年12月9日(土) 19:05:34, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.西川 裕美子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.西嶋 仁
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Matsumoto Minoru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.森本 純子 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.廣田 史子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Takahashi Satoru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Luche Hervé (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Fehring Hans Joerg (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Understanding the cellular dynamics of Aire-expressing lineage(s) among medullary thymic epithelial cells (AEL-mTECs) is essential for gaining insight into the roles of Aire in establishment of self-tolerance. In this study, we monitored the maturation program of AEL-mTECs by temporal lineage tracing, in which bacterial artificial chromosome transgenic mice expressing tamoxifen-inducible Cre recombinase under control of the Aire regulatory element were crossed with reporter strains. We estimated that the half-life of AEL-mTECs subsequent to Aire expression was ∼7-8 d, which was much longer than that reported previously, owing to the existence of a post-Aire stage. We found that loss of Aire did not alter the overall lifespan of AEL-mTECs, inconsistent with the previous notion that Aire expression in medullary thymic epithelial cells (mTECs) might result in their apoptosis for efficient cross-presentation of self-antigens expressed by AEL-mTECs. In contrast, Aire was required for the full maturation program of AEL-mTECs, as exemplified by the lack of physiological downregulation of CD80 during the post-Aire stage in Aire-deficient mice, thus accounting for the abnormally increased CD80(high) mTECs seen in such mice. Of interest, increased CD80(high) mTECs in Aire-deficient mice were not mTEC autonomous and were dependent on cross-talk with thymocytes. These results further support the roles of Aire in the differentiation program of AEL-mTECs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD80 (日) (読) [継承]
3. (英) Apoptosis (日) (読) [継承]
4. (英) Autoantigens (日) (読) [継承]
5. (英) Cell Differentiation (日) (読) [継承]
6. (英) Cell Lineage (日) (読) [継承]
7. (英) Cells, Cultured (日) (読) [継承]
8. (英) Cross-Priming (日) (読) [継承]
9. (英) Epithelial Cells (日) (読) [継承]
10. (英) Flow Cytometry (日) (読) [継承]
11. (英) Immunohistochemistry (日) (読) [継承]
12. (英) Kinetics (日) (読) [継承]
13. (英) Luminescent Proteins (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16. (英) Mice, Knockout (日) (読) [継承]
17. (英) Mice, Transgenic (日) (読) [継承]
18. (英) Thymocytes (日) (読) [継承]
19. (英) Thymus Gland (日) (読) [継承]
20. (英) Time Factors (日) (読) [継承]
21. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 192 [継承]
(必須): 6 [継承]
(必須): 2585 2592 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 2月 10日 (平成 26年 2月 10日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1302786    (→Scopusで検索) [継承]
PMID (任意): 24516201    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000332702700007 [継承]
Scopus (任意): 2-s2.0-84897508383 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.4049/jimmunol.1302786  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Joerg Hans Fehring, Yasuhiro Mouri and Mitsuru Matsumoto : Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program., The Journal of Immunology, Vol.192, No.6, 2585-2592, 2014.
欧文冊子 ● Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Joerg Hans Fehring, Yasuhiro Mouri and Mitsuru Matsumoto : Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program., The Journal of Immunology, Vol.192, No.6, 2585-2592, 2014.

関連情報

Number of session users = 4, LA = 0.69, Max(EID) = 372573, Max(EOID) = 996602.