『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Jenkinson S Rhiannon (日) (読)
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[継承]
2. (英) Williams Joy A (日) (読)
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[継承]
3. (英) Jeon Hyein (日) (読)
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[継承]
4. (英) Zhang Jingjing (日) (読)
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[継承]
5.新田 剛
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6.大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
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7. (英) Kruhlak Michael (日) (読)
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8. (英) Zuklys Saulius (日) (読)
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[継承]
9. (英) Sharrow Susan (日) (読)
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[継承]
10. (英) Adams Anthony (日) (読)
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11. (英) Granger Larry (日) (読)
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12. (英) Choi Yongwon (日) (読)
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[継承]
13. (英) Siebenlist Ulrich (日) (読)
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[継承]
14. (英) Bishop Gail A (日) (読)
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15. (英) Hollander Georg A (日) (読)
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16.高浜 洋介
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17. (英) Hodes Richard J (日) (読)
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題名 (必須): (英) TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Induction of self-tolerance in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in turn, requires signals from single-positive (SP) thymocytes. Thus, the absence of SP thymocytes in Tcra(-/-) mice results in a profound deficiency in mTECs. Here, we have probed the mechanism that underlies this requirement for cross-talk with thymocytes in medullary development. Previous studies have implicated nonclassical NF-B as a pathway important in the development of mTECs, because mice lacking RelB, NIK, or IKK, critical components of this pathway, have an almost complete absence of mTECs, with resulting autoimmune pathology. We therefore assessed the effect of selective deletion in TEC of TNF receptor-associated factor 3 (TRAF3), an inhibitor of nonclassical NF-B signaling. Deletion of TRAF3 in thymic epithelial cells allowed RelB-dependent development of normal numbers of AIRE-expressing mTECs in the complete absence of SP thymocytes. Thus, mTEC development can occur in the absence of cross-talk with SP thymocytes, and signals provided by SP T cells are needed to overcome TRAF3-imposed arrest in mTEC development mediated by inhibition of nonclassical NF-B. We further observed that TRAF3 deletion is also capable of overcoming all requirements for LTR and CD40, which are otherwise necessary for mTEC development, but is not sufficient to overcome the requirement for RANKL, indicating a role for RANKL that is distinct from the signals provided by SP thymocytes. We conclude that TRAF3 plays a central role in regulation of mTEC development by imposing requirements for SP T cells and costimulation-mediated cross-talk in generation of the medullary compartment.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD40 (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Flow Cytometry (日) (読) [継承]
5. (英) Immunohistochemistry (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Inbred C57BL (日) (読) [継承]
8. (英) Mice, Knockout (日) (読) [継承]
9. (英) Receptor Cross-Talk (日) (読) [継承]
10. (英) Self Tolerance (日) (読) [継承]
11. (英) T-Lymphocytes (日) (読) [継承]
12. (英) TNF Receptor-Associated Factor 3 (日) (読) [継承]
13. (英) Thymocytes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)

ISSN (任意): 1091-6490
ISSN: 0027-8424 (pISSN: 0027-8424, eISSN: 1091-6490)
Title: Proceedings of the National Academy of Sciences of the United States of America
Title(ISO): Proc Natl Acad Sci U S A
Publisher: National Academy of Sciences
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 110 [継承]
(必須): 52 [継承]
(必須): 21107 21112 [継承]
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年月日 (必須): 西暦 2013年 12月 9日 (平成 25年 12月 9日) [継承]
URL (任意):
DOI (任意): 10.1073/pnas.1314859111    (→Scopusで検索) [継承]
PMID (任意): 24324158    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Rhiannon S Jenkinson, A Joy Williams, Hyein Jeon, Jingjing Zhang, Takeshi Nitta, Izumi Ohigashi, Michael Kruhlak, Saulius Zuklys, Susan Sharrow, Anthony Adams, Larry Granger, Yongwon Choi, Ulrich Siebenlist, A Gail Bishop, A Georg Hollander, Yousuke Takahama and J Richard Hodes : TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development., Proceedings of the National Academy of Sciences of the United States of America, Vol.110, No.52, 21107-21112, 2013.
欧文冊子 ● Rhiannon S Jenkinson, A Joy Williams, Hyein Jeon, Jingjing Zhang, Takeshi Nitta, Izumi Ohigashi, Michael Kruhlak, Saulius Zuklys, Susan Sharrow, Anthony Adams, Larry Granger, Yongwon Choi, Ulrich Siebenlist, A Gail Bishop, A Georg Hollander, Yousuke Takahama and J Richard Hodes : TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development., Proceedings of the National Academy of Sciences of the United States of America, Vol.110, No.52, 21107-21112, 2013.

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