『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yano Kouta (日) (読)
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2. (英) Carter Christine (日) (読)
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3. (英) Yoshida Naofumi (日) (読)
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4. (英) Abe Takaya (日) (読)
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5.山田 安希子
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6.新田 剛
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7.石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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8.高田 健介
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9. (英) Butcher Geoffrey W (日) (読)
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10.高浜 洋介
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題名 (必須): (英) Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.  (日)    [継承]
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要約 (任意): (英) Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP-binding proteins of the Gimap family. Gimap3 and Gimap5, whose transcripts are abundant in mature lymphocytes, can associate with antiapoptotic Bcl-2 family proteins. While it is established that Gimap5 regulates T-cell survival, the in vivo role of Gimap3 is unclear. Here we report the preparation and characteristics of mouse strains lacking Gimap3 and/or Gimap5. We found that the number of T cells was markedly reduced in mice deficient in both Gimap3 and Gimap5. The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5 than in mice lacking only Gimap5. No defects in the cellularity of T cells were detected in mice lacking only Gimap3, whereas bone marrow cells from Gimap3-deficient mice showed reduced T-cell production in a competitive hematopoietic environment. Moreover, retroviral overexpression and short hairpin RNAs-mediated silencing of Gimap3 in bone marrow cells elevated and reduced, respectively, the number of T cells produced in irradiated mice. These results suggest that Gimap3 is a regulator of T-cell numbers in the mouse and that multiple Gimap family proteins cooperate to maintain T-cell survival.  (日)    [継承]
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誌名 (必須): European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)

ISSN (任意): 1521-4141
ISSN: 0014-2980 (pISSN: 0014-2980, eISSN: 1521-4141)
Title: European journal of immunology
Title(ISO): Eur J Immunol
Supplier: European Federation of Immunological Societies
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 44 [継承]
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(必須): 561 572 [継承]
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年月日 (必須): 西暦 2014年 2月 初日 (平成 26年 2月 初日) [継承]
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DOI (任意): 10.1002/eji.201343750    (→Scopusで検索) [継承]
PMID (任意): 24510501    (→Scopusで検索) [継承]
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WOS (任意): 000331901200026 [継承]
Scopus (任意): 2-s2.0-84893530167 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kouta Yano, Christine Carter, Naofumi Yoshida, Takaya Abe, Akiko Yamada, Takeshi Nitta, Naozumi Ishimaru, Kensuke Takada, W Geoffrey Butcher and Yousuke Takahama : Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse., European Journal of Immunology, Vol.44, No.2, 561-572, 2014.
欧文冊子 ● Kouta Yano, Christine Carter, Naofumi Yoshida, Takaya Abe, Akiko Yamada, Takeshi Nitta, Naozumi Ishimaru, Kensuke Takada, W Geoffrey Butcher and Yousuke Takahama : Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse., European Journal of Immunology, Vol.44, No.2, 561-572, 2014.

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