『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Adiningrat Arya (日) ARYA ADININGRAT (読) ありや あでぃにんらと
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学籍番号 (推奨): **** [ユーザ]
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2.谷村 綾子
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3.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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4. (英) Dwi Yanuaryska Ryna (日) RYNA DWI YANUARYSKA (読) りな どぅい やぬありすか
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学籍番号 (推奨): **** [ユーザ]
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5. (英) Hagita Hiroko (日) (読)
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6.堀口 大吾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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7.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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題名 (必須): (英) Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells.  (日)    [継承]
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要約 (任意): (英) Tooth development relies on the interaction between the oral ectoderm and underlying mesenchyme, and is regulated by a complex genetic cascade. This transcriptional cascade is regulated by the spatiotemporal activation and deactivation of transcription factors. The specificity proteins 6 (Sp6) and chicken ovalbumin upstream promoter transcription factor-interacting protein 2 (Ctip2) were identified in loss-of-function studies as key transcription factors required for tooth development. Ctip2 binds to the Sp6 promoter in vivo; however, its role in Sp6 expression remains unclear. In this study, we investigated Sp6 transcriptional regulation by Ctip2. Immunohistochemical analysis revealed that Sp6 and Ctip2 colocalize in the rat incisor during tooth development. We examined whether Ctip2 regulates Sp6 promoter activity in dental epithelial cells. Cotransfection experiments using serial Sp6 promoter-luciferase constructs and Ctip2 expression plasmids showed that Ctip2 significantly suppressed the Sp6 second promoter activity, although the Sp6 first promoter activity was unaffected. Ctip2 was able to bind to the proximal region of the Sp6 first promoter, as previously demonstrated, and also to the novel distal region of the first, and second promoter regions. Our findings indicate that Ctip2 regulates Sp6 gene expression through direct binding to the Sp6 second promoter region. J. Med. Invest. 61: 126-136, February, 2014.  (日)    [継承]
キーワード (推奨): 1. (英) ameloblast differentiation (日) (読) [継承]
2. (英) Ctip2 (日) (読) [継承]
3. (英) Sp6 (日) (読) [継承]
4. (英) tooth development (日) (読) [継承]
5. (英) transcriptional regulation (日) (読) [継承]
発行所 (推奨): (英) The University of Tokushima Faculty of Medicine (日) (読) [継承]
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 61 [継承]
(必須): 1.2 [継承]
(必須): 126 136 [継承]
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年月日 (必須): 西暦 2014年 2月 初日 (平成 26年 2月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/130004822699/ [継承]
DOI (任意): 10.2152/jmi.61.126    (→Scopusで検索) [継承]
PMID (任意): 24705758    (→Scopusで検索) [継承]
NAID (任意): 130004822699 [継承]
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Scopus (任意): 2-s2.0-84897946413 [継承]
機関リポジトリ : 109529 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Arya Adiningrat, Ayako Tanimura, Keiko Miyoshi, Ryna Yanuaryska Dwi, Hiroko Hagita, Taigo Horiguchi and Takafumi Noma : Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells., The Journal of Medical Investigation : JMI, Vol.61, No.1.2, 126-136, 2014.
欧文冊子 ● Arya Adiningrat, Ayako Tanimura, Keiko Miyoshi, Ryna Yanuaryska Dwi, Hiroko Hagita, Taigo Horiguchi and Takafumi Noma : Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells., The Journal of Medical Investigation : JMI, Vol.61, No.1.2, 126-136, 2014.

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