『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=276938)

EID=276938EID:276938, Map:0, LastModified:2017年11月27日(月) 18:33:56, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐藤 裕], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Pokorski Mieczyslaw (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Takeda Kotaro (日) (読)
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学籍番号 (推奨):
[継承]
3.佐藤 裕 ([徳島大学.大学院社会産業理工学研究部.社会総合科学域.人間科学系.心理学分野]/[徳島大学.総合科学部.社会総合科学科.心身健康コース])
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[継承]
4. (英) Okada Yasumasa (日) (読)
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[継承]
題名 (必須): (英) The hypoxic ventilatory response and TRPA1 antagonism in conscious mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Recently, TRPA1 channels, richly expressed in both peripheral and central neural systems, have been proposed as novel sensors of changes in oxygen concentration along the hypoxic-hyperoxic continuum. In this study, we investigated the hypothesis that TRPA1 channels blockade should profoundly affect the hypoxic ventilatory response (HVR). We examined the chemosensory ventilatory responses in conscious mice before and after intraperitoneal administration of the specific TRPA1 antagonist HC-030031 in two doses of 50 and 200 (cumulative dose 250) mg kg(-1) . Ventilation and its responses to mild 13% and severe 7% hypoxia, pure O2 , and 5% CO2 in O2 were recorded in a whole-body plethysmograph. TRPA1 antagonism caused a dose-dependent attenuation of the HVR. Ventilatory stimulation was virtually abrogated in response to the mild, but it remained viable, albeit slashed, at severe hypoxia after the bigger dose of HC-030031. The TRPA1 function seemed specific for the hypoxic chemoreflex as neither the response to pure O2 nor hypercapnia was appreciably influenced by the TRPA1 antagonist. The study unravelled the role of TRPA1 in shaping the ventilatory response to low-intensity hypoxia, liable to be mediated by vagally innervated respiratory chemosensors of lower functional rank, but contradicted the TRPA1 being indispensable for the powerful carotid body chemoreflex in face of a severe hypoxic threat.  (日)    [継承]
キーワード (推奨): 1. (英) Acetanilides (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Anoxia (日) (読) [継承]
4. (英) Carotid Body (日) (読) [継承]
5. (英) Dose-Response Relationship, Drug (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Oxygen Consumption (日) (読) [継承]
11. (英) Pulmonary Ventilation (日) (読) [継承]
12. (英) Purines (日) (読) [継承]
13. (英) Transient Receptor Potential Channels (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Acta Physiologica (Scandinavian Society for Physiology/Federation of European Physiological Societies)
(pISSN: 1748-1708, eISSN: 1748-1716)

ISSN (任意): 1748-1716
ISSN: 1748-1708 (pISSN: 1748-1708, eISSN: 1748-1716)
Title: Acta physiologica (Oxford, England)
Title(ISO): Acta Physiol (Oxf)
Supplier: Federation of European Physiological Societies
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 210 [継承]
(必須): 4 [継承]
(必須): 928 938 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 4月 初日 (平成 26年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/apha.12202    (→Scopusで検索) [継承]
PMID (任意): 24245768    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000332757600023 [継承]
Scopus (任意): 2-s2.0-84896036395 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/apha.12202  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: carotid chemoreceptors  (日)    [継承]
5.(英) KeywordList.Keyword: chemosensing  (日)    [継承]
6.(英) KeywordList.Keyword: hypercapnia  (日)    [継承]
7.(英) KeywordList.Keyword: hyperventilation  (日)    [継承]
8.(英) KeywordList.Keyword: hypoxia  (日)    [継承]
9.(英) KeywordList.Keyword: oxygen sensor  (日)    [継承]

標準的な表示

和文冊子 ● Mieczyslaw Pokorski, Kotaro Takeda, Yutaka Sato and Yasumasa Okada : The hypoxic ventilatory response and TRPA1 antagonism in conscious mice., Acta Physiologica, Vol.210, No.4, 928-938, 2014.
欧文冊子 ● Mieczyslaw Pokorski, Kotaro Takeda, Yutaka Sato and Yasumasa Okada : The hypoxic ventilatory response and TRPA1 antagonism in conscious mice., Acta Physiologica, Vol.210, No.4, 928-938, 2014.

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