『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=276336EID:276336, Map:0, LastModified:2017年11月27日(月) 18:34:09, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[永廣 信治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.多田 恵曜 ([徳島大学.病院.中央診療施設等.てんかんセンター])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kosuke Wada (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.島田 健司 ([徳島大学.病院.中央診療施設等.地域脳神経外科診療部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Hiroshi Makino (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Liang EI (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Shoko Murakami (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Mari Kudo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Kitazato KT (日) 北里 慶子 (読) きたざと けいこ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.永廣 信治
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Tomoki Hashimoto (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Roles of hypertension in the rupture of intracranial aneurysms  (日)    [継承]
副題 (任意):
要約 (任意): (英) Systemic hypertension has long been considered a risk factor of aneurysmal rupture. However, a causal link between systemic hypertension and the development of aneurysmal rupture has not been established. In this study, using a mouse model of intracranial aneurysm rupture, we examined the roles of systemic hypertension in the development of aneurysmal rupture. Aneurysms were induced by a combination of deoxycorticosterone acetate (DOCA)-salt and a single injection of elastase into the cerebrospinal fluid in mice. Antihypertensive treatment was started 6 days after aneurysm induction. Aneurysmal rupture was detected by neurological symptoms and confirmed by the presence of intracranial aneurysm with subarachnoid hemorrhage. Hydralazine (direct vasodilator) or discontinuation of DOCA-salt treatment was used to assess the roles of systemic hypertension. Captopril (angiotensin-converting enzyme inhibitor) or losartan (angiotensin II type 1 receptor antagonist) was used to assess the roles of the local renin-angiotensin system in the vascular wall. Normalization of blood pressure by hydralazine significantly reduced the incidence of ruptured aneurysms and the rupture rate. There was a dose-dependent relationship between reduction of blood pressure and prevention of aneurysmal rupture. Captopril and losartan were able to reduce rupture rate without affecting systemic hypertension induced by DOCA-salt treatment. Normalization of blood pressure after aneurysm formation prevented aneurysmal rupture in mice. In addition, we found that the inhibition of the local renin-angiotensin system independent from the reduction of blood pressure can prevent aneurysmal rupture.  (日)    [継承]
キーワード (推奨): 1. (英) Aneurysm, Ruptured (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antihypertensive Agents (日) (読) [継承]
4. (英) Blood Pressure (日) (読) [継承]
5. (英) Captopril (日) (読) [継承]
6. (英) Desoxycorticosterone Acetate (日) (読) [継承]
7. (英) Dose-Response Relationship, Drug (日) (読) [継承]
8. (英) Hydralazine (日) (読) [継承]
9. (英) Hypertension (日) (読) [継承]
10. (英) Intracranial Aneurysm (日) (読) [継承]
11. (英) Losartan (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Pancreatic Elastase (日) (読) [継承]
16. (英) Renin-Angiotensin System (日) (読) [継承]
17. (英) Risk Factors (日) (読) [継承]
18. (英) Subarachnoid Hemorrhage (日) (読) [継承]
19. (英) Survival Analysis (日) (読) [継承]
20. (英) Treatment Outcome (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Stroke ([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)

ISSN (任意): 1524-4628
ISSN: 0039-2499 (pISSN: 0039-2499, eISSN: 1524-4628)
Title: Stroke
Title(ISO): Stroke
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 45 [継承]
(必須): 2 [継承]
(必須): 579 586 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 2月 初日 (平成 26年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1161/STROKEAHA.113.003072    (→Scopusで検索) [継承]
PMID (任意): 24370755    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000330312500050 [継承]
Scopus (任意): 2-s2.0-84893815565 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1161/STROKEAHA.113.003072  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: NIHMS543498  (日)    [継承]
6.(英) OtherID: PMC3935821  (日)    [継承]
7.(英) KeywordList.Keyword: angiotensins  (日)    [継承]
8.(英) KeywordList.Keyword: hypertension  (日)    [継承]
9.(英) KeywordList.Keyword: intracranial aneurysm  (日)    [継承]
10.(英) KeywordList.Keyword: models, animal  (日)    [継承]
11.(英) KeywordList.Keyword: subarachnoid hemorrhage  (日)    [継承]

標準的な表示

和文冊子 ● Yoshiteru Tada, Wada Kosuke, Kenji Shimada, Makino Hiroshi, EI Liang, Murakami Shoko, Kudo Mari, KT Kitazato, Shinji Nagahiro and Hashimoto Tomoki : Roles of hypertension in the rupture of intracranial aneurysms, Stroke, Vol.45, No.2, 579-586, 2014.
欧文冊子 ● Yoshiteru Tada, Wada Kosuke, Kenji Shimada, Makino Hiroshi, EI Liang, Murakami Shoko, Kudo Mari, KT Kitazato, Shinji Nagahiro and Hashimoto Tomoki : Roles of hypertension in the rupture of intracranial aneurysms, Stroke, Vol.45, No.2, 579-586, 2014.

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