『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=274603EID:274603, Map:0, LastModified:2018年5月4日(金) 21:05:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.楊 諦
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学籍番号 (推奨): **** [ユーザ]
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2.岡村 裕彦
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3.中島 義基
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4.羽地 達次
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題名 (必須): (英) Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and Osterix  (日)    [継承]
副題 (任意):
要約 (任意): (英) Post-translational modifications of histones including methylation play important roles in cell differentiation. Jumonji domain-containing 3 (Jmjd3) is a histone demethylase, which specifically catalyzes the removal of trimethylation of histone H3 at lysine 27 (H3K27me3). In this study, we examined the expression of Jmjd3 in osteoblasts and its roles in osteoblast differentiation. Jmjd3 expression in the nucleus was induced in response to the stimulation of osteoblast differentiation as well as treatment of bone morphogenetic protein-2 (BMP-2). Either treatment with Noggin, an inhibitor of BMP-2, or silencing of Smad1/5 suppressed Jmjd3 expression during osteoblast differentiation. Silencing of Jmjd3 expression suppressed osteoblast differentiation through the expression of bone-related genes including Runx2, osterix, osteopontin, bone sialoprotein (BSP), and osteocalcin (OCN). Silencing of Jmjd3 decreased the promoter activities of Runx2 and osterix and increased the level of H3K27me3 on the promoter regions of Runx2 and osterix. Introduction of the exogenous Runx2 and osterix partly rescued osteoblast differentiation in the shJmjd3 cells. The present results indicate that Jmjd3 plays important roles in osteoblast differentiation and regulates the expressions of BSP and OCN via transcription factors Runx2 and osterix.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.細胞分化 (cell differentiation) [継承]
3. (英) Cell Nucleus (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Core Binding Factor Alpha 1 Subunit (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Histones (日) (読) [継承]
8. (英) Jumonji Domain-Containing Histone Demethylases (日) (読) [継承]
9. (英) Methylation (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Osteoblasts (日) (読) [継承]
12.オステオポンティン (osteopontin) [継承]
13. (英) Promoter Regions, Genetic (日) (読) [継承]
14. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 288 [継承]
(必須): 47 [継承]
(必須): 33530 33541 [継承]
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年月日 (必須): 西暦 2013年 10月 8日 (平成 25年 10月 8日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M113.497040    (→Scopusで検索) [継承]
PMID (任意): 24106268    (→Scopusで検索) [継承]
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WOS (任意): 000327250200004 [継承]
Scopus (任意): 2-s2.0-84888323756 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1074/jbc.M113.497040  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC3837102 [Available on 11/22/14]  (日)    [継承]
5.(英) KeywordList.Keyword: Bone  (日)    [継承]
6.(英) KeywordList.Keyword: Bone morphogenetic protein (BMP)  (日)    [継承]
7.(英) KeywordList.Keyword: Differentiation  (日)    [継承]
8.(英) KeywordList.Keyword: Histone methylation  (日)    [継承]
9.(英) KeywordList.Keyword: Osteoblasts  (日)    [継承]

標準的な表示

和文冊子 ● Di Yang, Hirohiko Okamura, Yoshiki Nakashima and Tatsuji Haneji : Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and Osterix, The Journal of Biological Chemistry, Vol.288, No.47, 33530-33541, 2013.
欧文冊子 ● Di Yang, Hirohiko Okamura, Yoshiki Nakashima and Tatsuji Haneji : Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and Osterix, The Journal of Biological Chemistry, Vol.288, No.47, 33530-33541, 2013.

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