『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=273373EID:273373, Map:0, LastModified:2013年11月20日(水) 15:10:20, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[佐々木 卓也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.坂根 亜由子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生化学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Abdallah Alamir Mahmoud Ahmed (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Nakano Kiyoshi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Honda Kazufumi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Ikeda Wataru (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Nishikawa Yumiko (日) (読)
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学籍番号 (推奨):
[継承]
7.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Matsushita Natsuki (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Kitamura Toshio (日) (読)
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学籍番号 (推奨):
[継承]
10.佐々木 卓也 ([徳島大学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development.  (日)    [継承]
副題 (任意):
要約 (任意): (英) During epithelial junctional development, both vesicle transport and reorganization of the actin cytoskeleton must be spatiotemporally regulated. Coordination of these cellular functions is especially important, but the precise mechanism remains elusive. Previously, we identified junctional Rab13-binding protein (JRAB)/molecules interacting with CasL-like 2 (MICAL-L2) as an effector of the Rab13 small G protein, and we found that the Rab13-JRAB system may be involved in the formation of cell-cell adhesions via transport of adhesion molecules. Here, we showed that JRAB interacts with two actin-binding proteins, actinin-1 and -4, and filamentous actin via different domains and regulates actin cross-linking and stabilization through these interactions. During epithelial junctional development, JRAB is prominently enriched in the actin bundle at the free border; subsequently, JRAB undergoes a Rab13-dependent conformational change that is required for maturation of cell-cell adhesion sites. These results suggest that Rab13 and JRAB regulate reorganization of the actin cytoskeleton throughout epithelial junctional development from establishment to maturation of cell-cell adhesion.  (日)    [継承]
キーワード (推奨): 1. (英) Actin Cytoskeleton (日) (読) [継承]
2. (英) Actinin (日) (読) [継承]
3. (英) Actins (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Cell Membrane (日) (読) [継承]
7. (英) Cytoskeletal Proteins (日) (読) [継承]
8. (英) Epithelial Cells (日) (読) [継承]
9. (英) Epithelium (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Models, Biological (日) (読) [継承]
13. (英) Protein Binding (日) (読) [継承]
14. (英) Protein Multimerization (日) (読) [継承]
15. (英) Protein Structure, Tertiary (日) (読) [継承]
16. (英) Protein Transport (日) (読) [継承]
17. (英) Tight Junctions (日) (読) [継承]
18. (英) rab GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 287 [継承]
(必須): 51 [継承]
(必須): 42455 42468 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 10月 24日 (平成 24年 10月 24日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M112.383653    (→Scopusで検索) [継承]
PMID (任意): 23100251    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1074/jbc.M112.383653  (日)    [継承]
2.(英) Article.Affiliation: Department of Biochemistry, Institute of Health Biosciences, Graduate School, Faculty of Medicine, University of Tokushima , Tokushima, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: PMC3522248 [Available on 12/14/13]  (日)    [継承]

標準的な表示

和文冊子 ● Ayuko Sakane, Ahmed Alamir Mahmoud Abdallah, Kiyoshi Nakano, Kazufumi Honda, Wataru Ikeda, Yumiko Nishikawa, Mitsuru Matsumoto, Natsuki Matsushita, Toshio Kitamura and Takuya Sasaki : Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development., The Journal of Biological Chemistry, Vol.287, No.51, 42455-42468, 2012.
欧文冊子 ● Ayuko Sakane, Ahmed Alamir Mahmoud Abdallah, Kiyoshi Nakano, Kazufumi Honda, Wataru Ikeda, Yumiko Nishikawa, Mitsuru Matsumoto, Natsuki Matsushita, Toshio Kitamura and Takuya Sasaki : Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development., The Journal of Biological Chemistry, Vol.287, No.51, 42455-42468, 2012.

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