『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=273323)

EID=273323EID:273323, Map:0, LastModified:2014年10月21日(火) 15:04:03, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Odaka Chikako (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Hauri-Hohl Mathias (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Takizawa Kazuya (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Nishikawa Yumiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yano Masashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Boyd Richard (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Hollander A. George (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Hassall's corpuscles are concentric clusters of keratinized epithelial cells located within the thymic medulla of humans and guinea pigs but are scant in mouse and rat. They are considered to be the terminally differentiated stages of medullary thymic epithelial cells (mTECs) but the mechanisms of their origin are unclear. We have previously deleted the TGF-β type II receptor (TGFβRII) specifically in mouse TECs and reported that these mice have mitigated thymic involution and exhibit earlier reconstitution post-irradiation. In this study, we analyzed the differentiation of mTECs in the TGFβRII-knockout mice. Interestingly, the TGFβRII-knockout mice display enhanced development of Hassall's corpuscles. The expression of Aire, stromal-cell-derived factor 1 and thymic stromal lymphopoietin in the thymi of the TGFβRII-knockout mice was similar to that previously reported for the human thymus. In addition, the putative epithelial progenitor markers MTS20 and MTS24 labeled Hassall's corpuscles in normal mice, but the extent and intensity of this staining were greatly enhanced in Hassall's corpuscles of the TGFβRII-knockout mice. The phosphorylated forms of ERK and JNK were also found in Hassall's corpuscles of the TGFβRII-knockout mice. Taken together, we suggest that TGFβRII-mediated signaling in TECs inhibits their development into Hassall's corpuscles in mice.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): International Immunology ([Oxford University Press])
(pISSN: 0953-8178, eISSN: 1460-2377)

ISSN (任意): 1460-2377
ISSN: 0953-8178 (pISSN: 0953-8178, eISSN: 1460-2377)
Title: International immunology
Title(ISO): Int Immunol
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 25 [継承]
(必須): 11 [継承]
(必須): 633 642 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 11月 1日 (平成 25年 11月 1日) [継承]
URL (任意):
DOI (任意): 10.1093/intimm/dxt026    (→Scopusで検索) [継承]
PMID (任意): 23929912    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000326375900003 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto-cho Tokushima 770-8503, Japan. toshio.matsumoto@tokushima-u.ac.jp.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Chikako Odaka, Mathias Hauri-Hohl, Kazuya Takizawa, Yumiko Nishikawa, Masashi Yano, Mitsuru Matsumoto, Richard Boyd and George A. Hollander : TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice, International Immunology, Vol.25, No.11, 633-642, 2013.
欧文冊子 ● Chikako Odaka, Mathias Hauri-Hohl, Kazuya Takizawa, Yumiko Nishikawa, Masashi Yano, Mitsuru Matsumoto, Richard Boyd and George A. Hollander : TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice, International Immunology, Vol.25, No.11, 633-642, 2013.

関連情報

Number of session users = 6, LA = 0.59, Max(EID) = 372573, Max(EOID) = 996585.