『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=272772EID:272772, Map:0, LastModified:2014年2月27日(木) 16:47:37, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Higashikuni Y (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Tanaka K (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Kato M (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Nureki O (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Hirata Y (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Nagai R (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Komuro I (日) (読)
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学籍番号 (推奨):
[継承]
8.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Toll-Like Receptor-2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin-1 Upregulation via Nuclear Factor B Activation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Background: Inflammation is induced in the heart during the development of cardiac hypertrophy. The initiating mechanisms and the role of inflammation in cardiac hypertrophy, however, remain unclear. Toll-like receptor2 (TLR2) recognizes endogenous molecules that induce noninfectious inflammation. Here, we examined the role of TLR2mediated inflammation in cardiac hypertrophy. Methods and Results: At 2 weeks after transverse aortic constriction, Tlr2/ mice showed reduced cardiac hypertrophy and fibrosis with greater left ventricular dilatation and impaired systolic function compared with wildtype mice, which indicated impaired cardiac adaptation in Tlr2/ mice. Bone marrow transplantation experiment revealed that TLR2 expressed in the heart, but not in bone marrowderived cells, is important for cardiac adaptive response to pressure overload. In vitro experiments demonstrated that TLR2 signaling can induce cardiomyocyte hypertrophy and fibroblast and vascular endothelial cell proliferation through nuclear factorB activation and interleukin1 upregulation. Systemic administration of a nuclear factorB inhibitor or antiinterleukin1 antibodies to wildtype mice resulted in impaired adaptive cardiac hypertrophy after transverse aortic constriction. We also found that heat shock protein 70, which was increased in murine plasma after transverse aortic constriction, can activate TLR2 signaling in vitro and in vivo. Systemic administration of antiheat shock protein 70 antibodies to wildtype mice impaired adaptive cardiac hypertrophy after transverse aortic constriction. Conclusions: Our results demonstrate that TLR2mediated inflammation induced by extracellularly released heat shock protein 70 is essential for adaptive cardiac hypertrophy in response to pressure overload. Thus, modulation of TLR2 signaling in the heart may provide a novel strategy for treating heart failure due to inadequate adaptation to hemodynamic stress.  (日)    [継承]
キーワード (推奨): 1.心不全 (heart failure) [継承]
2. (英) hypertrophy (日) (読) [継承]
3.炎症 (inflammation) [継承]
4. (英) interleukins (日) (読) [継承]
5. (英) signal transduction (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Journal of the American Heart Association ([American Heart Association]/American Stroke Association)
(eISSN: 2047-9980)

ISSN (任意): 2047-9980
ISSN: 2047-9980 (eISSN: 2047-9980)
Title: Journal of the American Heart Association
Title(ISO): J Am Heart Assoc
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 2 [継承]
(必須): 6 [継承]
(必須): e000267 e000267 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 11月 18日 (平成 25年 11月 18日) [継承]
URL (任意):
DOI (任意): 10.1161/JAHA.113.000267    (→Scopusで検索) [継承]
PMID (任意): 24249711    (→Scopusで検索) [継承]
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WOS (任意): 000330177900018 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1161/JAHA.113.000267  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC3886766  (日)    [継承]
5.(英) KeywordList.Keyword: heart failure  (日)    [継承]
6.(英) KeywordList.Keyword: hypertrophy  (日)    [継承]
7.(英) KeywordList.Keyword: inflammation  (日)    [継承]
8.(英) KeywordList.Keyword: interleukins  (日)    [継承]
9.(英) KeywordList.Keyword: signal transduction  (日)    [継承]

標準的な表示

和文冊子 ● Y Higashikuni, K Tanaka, M Kato, O Nureki, Y Hirata, R Nagai, I Komuro and Masataka Sata : Toll-Like Receptor-2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin-1 Upregulation via Nuclear Factor B Activation., Journal of the American Heart Association, Vol.2, No.6, e000267, 2013.
欧文冊子 ● Y Higashikuni, K Tanaka, M Kato, O Nureki, Y Hirata, R Nagai, I Komuro and Masataka Sata : Toll-Like Receptor-2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin-1 Upregulation via Nuclear Factor B Activation., Journal of the American Heart Association, Vol.2, No.6, e000267, 2013.

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