『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Ishizawa Keisuke (日) (読)
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2.広瀬 隆則
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3. (英) Sugiyama Kazuhiko (日) (読)
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4.影治 照喜
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5. (英) Nobusawa Sumihito (日) (読) のぶさわ すみひと
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6. (英) Homma Taku (日) (読) ほんま たく
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7. (英) Komori Takashi (日) (読) こもり たかし
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8.佐々木 敦史 ([徳島大学.先端技術科学教育部.システム創生工学専攻.知能情報システム工学コース])
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題名 (必須): (英) Pathologic diversity of glioneuronal tumor with neuropil-like islands: A histological and immunohistochemical study with a special reference to isocitrate dehydrogenase 1 (IDH1) in 5 cases  (日)    [継承]
副題 (任意):
要約 (任意): (英) Glioneuronal tumor with neuropil-like islands (GTNI) is featured by "neuropil-like islands (NIs)" within dominating astroglial components. Isocitrate dehydrogenase (IDH) mutations, particularly IDH1 R132H (G395A), are found in WHO Grade II and III diffuse gliomas as well as secondary, but not primary, glioblastomas. We reviewed 5 cases of GTNI, and assessed histology and immunohistochemistry with various antibodies, including those for IDH1 R132H, as well as direct DNA sequencing for IDH1 G395A. NIs were variable in morphology, and constantly synaptophysin-positive and glial fibrillary acidic protein-negative. The glioma components were primary glioblastoma in 2 cases, anaplastic astrocytoma in 1 and anaplastic oligoastrocytoma in 2. The IDH1 R132H was expressed in the 2 cases with oligoastrocytoma: In 1, NIs and the astrocytoma-like area as well as the oligodendroglioma-like area were positive. In the other, only the oligodendrogliomalike area was positive. The mutation analysis performed on the latter case with DNA separately sampled from the oligodendroglioma- like area and the astrocytoma-like area detected IDH1 G395A in both areas. We have shown diverse pathologic aspects of GTNI. Also, we have shown that the expression of IDH1 R132H in GTNI is largely concordant with that in diffuse gliomas, and that it can be dependent on each histologic component although the mutant IDH1 gene is ubiquitously present within the tumor.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Astrocytoma (日) (読) [継承]
3. (英) Brain Neoplasms (日) (読) [継承]
4. (英) DNA Mutational Analysis (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Isocitrate Dehydrogenase (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Middle Aged (日) (読) [継承]
10. (英) Oligodendroglioma (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical Neuropathology (Dustri-Verlag Dr. Karl Feistle)
(pISSN: 0722-5091)

ISSN (任意): 0722-5091
ISSN: 0722-5091 (pISSN: 0722-5091)
Title: Clinical neuropathology
Title(ISO): Clin. Neuropathol.
Publisher: Dustri-Verlag Dr. Karl Feistle
 (NLM Catalog  (CrossRef (Scopus information is found. [need login])
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(必須): 67 76 [継承]
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年月日 (必須): 西暦 2012年 3月 初日 (平成 24年 3月 初日) [継承]
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DOI (任意): 10.5414/NP300402    (→Scopusで検索) [継承]
PMID (任意): 22385787    (→Scopusで検索) [継承]
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WOS (任意): 000301822700003 [継承]
Scopus (任意): 2-s2.0-84863990857 [継承]
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備考 (任意): 1.(英)   (日) 著者1 同姓同名確認済み 参照不可   [継承]
2.(英) Article.Affiliation: Department of Pathology, Saitama Medical University, Saitama, Japan. ishizawa@saitama-med.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
5.(英) MedlineDate: 2012 Mar-Apr  (日)    [継承]

標準的な表示

和文冊子 ● Keisuke Ishizawa, Takanori Hirose, Kazuhiko Sugiyama, Teruyoshi Kageji, Sumihito Nobusawa, Taku Homma, Takashi Komori and Atsushi Sasaki : Pathologic diversity of glioneuronal tumor with neuropil-like islands: A histological and immunohistochemical study with a special reference to isocitrate dehydrogenase 1 (IDH1) in 5 cases, Clinical Neuropathology, Vol.31, No.2, 67-76, 2012.
欧文冊子 ● Keisuke Ishizawa, Takanori Hirose, Kazuhiko Sugiyama, Teruyoshi Kageji, Sumihito Nobusawa, Taku Homma, Takashi Komori and Atsushi Sasaki : Pathologic diversity of glioneuronal tumor with neuropil-like islands: A histological and immunohistochemical study with a special reference to isocitrate dehydrogenase 1 (IDH1) in 5 cases, Clinical Neuropathology, Vol.31, No.2, 67-76, 2012.

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