| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 影治 照喜
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| 2. | 永廣 信治
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| 3. | 松﨑 和仁
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| 4. | 溝渕 佳史
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| 5. | (英) Toi H (日) 戸井 宏行 (読) とい ひろゆき
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| 6. | (英) Nakagawa Y (日) 中川 義信 (読) なかがわ よしのぶ
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| 7. | (英) Kumada H (日) 熊田 博明 (読) くまだ ひろあき
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| ○題名 (必須): | □ | (英) Boron neutron capture therapy using mixed epithermal and thermal neutron beams in patients with malignant glioma-correlation between radiation dose and radiation injury and clinical outcome (日)
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| ○要約 (任意): | □ | (英) To clarify the correlation between the radiation dose and clinical outcome of sodium borocaptate-based intraoperative boron neutron capture therapy in patients with malignant glioma. The first protocol (P1998, n = 8) prescribed a maximal gross tumor volume (GTV) dose of 15 Gy. In 2001, a dose-escalated protocol was introduced (P2001, n = 11), which prescribed a maximal vascular volume dose of 15 Gy or, alternatively, a clinical target volume (CTV) dose of 18 Gy. The GTV and CTV doses in P2001 were 1.1-1.3 times greater than those in P1998. The maximal vascular volume dose of those with acute radiation injury was 15.8 Gy. The mean GTV and CTV dose in long-term survivors with glioblastoma was 26.4 and 16.5 Gy, respectively. A statistically significant correlation between the GTV dose and median survival time was found. In the 11 glioblastoma patients in P2001, the median survival time was 19.5 months and 1- and 2-year survival rate was 60.6% and 37.9%, respectively. Dose escalation contributed to the improvement in clinical outcome. To avoid radiation injury, the maximal vascular volume dose should be <12 Gy. For long-term survival in patients with glioblastoma after boron neutron capture therapy, the optimal mean dose of the GTV and CTV was 26 and 16 Gy, respectively. (日)
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| ○キーワード (推奨): | 1. | (英) Adolescent (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Aged (日) (読)
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| 4. | (英) Borohydrides (日) (読)
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| 5. | (英) Boron Neutron Capture Therapy (日) (読)
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| 6. | (英) Brain Neoplasms (日) (読)
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| 7. | (英) Child (日) (読)
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| 8. | (英) Child, Preschool (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Glioblastoma (日) (読)
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| 11. | (英) Humans (日) (読)
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| 12. | (英) Infant (日) (読)
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| 13. | (英) Magnetic Resonance Imaging (日) (読)
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| 14. | (英) Male (日) (読)
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| 15. | (英) Middle Aged (日) (読)
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| 16. | (英) Neuroectodermal Tumors, Primitive (日) (読)
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| 17. | (英) Radiotherapy Dosage (日) (読)
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| 18. | (英) Sulfhydryl Compounds (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Radiation Oncology*Biology*Physics ([Elsevier])
(pISSN: 0360-3016, eISSN: 1879-355X)
| ○ISSN (任意): | □ | 0360-3016
ISSN: 0360-3016
(pISSN: 0360-3016, eISSN: 1879-355X) Title: International journal of radiation oncology, biology, physicsTitle(ISO): Int J Radiat Oncol Biol PhysPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 65
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1446 1455
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 6月 5日 (平成 18年 6月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ijrobp.2006.03.016 (→Scopusで検索)
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| ○PMID (任意): | □ | 16750328 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Neurosurgery, Graduate School of Health Biosciences, The University of Tokushima, Tokushima, Japan. kageji@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Case Reports (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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