| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kijima Mika (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Yamaguchi Takeshi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 前川 洋一
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Koyanagi Akemi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Yagita HIdeo (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Chiba Shigeru (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Kishihara Kenji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Natural killer (NK) cells regulate various immune responses by exerting cytotoxic activity or secreting cytokines. The interaction of NK cells with dendritic cells (DC) contributes to NK cell-mediated antitumor or antimicrobial responses. However, the cellular and molecular mechanisms for controlling this interaction are largely unknown. Here, we show an involvement of Jagged2-Notch interaction in augmenting NK cell cytotoxicity mediated by DC. Enforced expression of Jagged2 on A20 cells (Jag2-A20 cells) suppressed their growth in vivo, which was abrogated by depleting NK cells. Moreover, Jag2-A20 cells exerted a suppression on the growth of nonmanipulated A20 cells in SCID mice in an NK-dependent manner. Consistently, coinoculation of A20 cells with DC overexpressing Jagged2 (Jag2-DC) suppressed the growth of A20 cells in mice. Stimulation of NK cells with Jagged2 directly enhanced their cytotoxicity, IFN-gamma production, and proliferation. Ligation of Notch2 on NK cells enhanced their cytotoxic activity, and Jag2-DC or CpG-treated DC-mediated NK cell cytotoxicity was suppressed by a gamma-secretase inhibitor. These results indicate that the Jagged2-Notch axis plays a crucial role in DC-mediated NK cell cytotoxicity. Furthermore, manipulation of this interaction may provide an approach to induce potent tumor immunity or to inhibit certain autoimmune diseases caused by NK cell activation. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Cell Proliferation (日) (読)
| [継承] |
| 3. | (英) Cell Transplantation (日) (読)
| [継承] |
| 4. | (英) Cytotoxicity, Immunologic (日) (読)
| [継承] |
| 5. | (英) Dendritic Cells (日) (読)
| [継承] |
| 6. | (英) Immunotherapy, Adoptive (日) (読)
| [継承] |
| 7. | (英) Killer Cells, Natural (日) (読)
| [継承] |
| 8. | (英) Lymphocyte Activation (日) (読)
| [継承] |
| 9. | (英) Membrane Proteins (日) (読)
| [継承] |
| 10. | (英) Mice (日) (読)
| [継承] |
| 11. | (英) Mice, Inbred BALB C (日) (読)
| [継承] |
| 12. | (英) Mice, SCID (日) (読)
| [継承] |
| 13. | (英) Neoplasms (日) (読)
| [継承] |
| 14. | (英) Protein Binding (日) (読)
| [継承] |
| 15. | (英) Receptors, Notch (日) (読)
| [継承] |
| 16. | シグナル伝達 (signal transduction)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 1091-6490
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 105
| [継承] |
| ○号 (必須): | □ | 19
| [継承] |
| ○頁 (必須): | □ | 7010 7015
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 5月 13日 (平成 20年 5月 13日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.0709919105 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 18458347 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1073/pnas.0709919105 (日)
| [継承] |
| 2. | (英) Article.Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan. (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |
| 5. | (英) OtherID: PMC2383942 (日)
| [継承] |