『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=269307)

EID=269307EID:269307, Map:0, LastModified:2013年12月9日(月) 15:14:28, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[布川 朋也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1.布川 朋也 ([徳島大学.病院.診療科.外科.泌尿器科])
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学籍番号 (推奨):
[継承]
2. (英) Ono Masaya (日) (読)
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学籍番号 (推奨):
[継承]
3.松尾 泰佑
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学籍番号 (推奨):
[継承]
4.上原 久典 ([徳島大学.病院.中央診療施設等.病理部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Miki Tsuneharu (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Nakamura Yusuke (日) (読)
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[継承]
7.金山 博臣 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
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学籍番号 (推奨):
[継承]
8.片桐 豊雅 (副理事 (研究支援担当)/先端酵素学研究所長)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas  (日)    [継承]
副題 (任意):
要約 (任意): (英) Studies of renal cell carcinoma (RCC) have led to the development of new molecular-targeted drugs but its oncogenic origins remain poorly understood. Here, we report the identification and critical roles in renal carcinogenesis for DDX31, a novel nucleolar protein upregulated in the vast majority of human RCC. Immunohistochemical overexpression of DDX31 was an independent prognostic factor for patients with RCC. RNA interference (RNAi)-mediated attenuation of DDX31 in RCC cells significantly suppressed outgrowth, whereas ectopic DDX31 overexpression in human 293 kidney cells drove their proliferation. Endogenous DDX31 interacted and colocalized with nucleophosmin (NPM1) in the nucleoli of RCC cells, and attenuation of DDX31 or NPM1 expression decreased pre-ribosomal RNA biogenesis. Notably, in DDX31-attenuated cells, NPM1 was translocated from nucleoli to the nucleoplasm or cytoplasm where it bound to HDM2. As a result, HDM2 binding to p53 was reduced, causing p53 stablization with concomitant G(1) phase cell-cycle arrest and apoptosis. Taken together, our findings define a mechanism through which control of the DDX31-NPM1 complex is likely to play critical roles in renal carcinogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) COS Cells (日) (読) [継承]
3. (英) Carcinoma, Renal Cell (日) (読) [継承]
4. (英) Cell Nucleolus (日) (読) [継承]
5. (英) DEAD-box RNA Helicases (日) (読) [継承]
6. (英) HEK293 Cells (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) Kidney Neoplasms (日) (読) [継承]
10. (英) Nuclear Proteins (日) (読) [継承]
11. (英) Prognosis (日) (読) [継承]
12. (英) Proto-Oncogene Proteins c-mdm2 (日) (読) [継承]
13. (英) RNA, Ribosomal (日) (読) [継承]
14.シグナル伝達 (signal transduction) [継承]
15. (英) Transcription, Genetic (日) (読) [継承]
16. (英) Transfection (日) (読) [継承]
17. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
18. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Research (American Assotiation for Cancer Research)
(pISSN: 0008-5472, eISSN: 1538-7445)

ISSN (任意): 1538-7445
ISSN: 0008-5472 (pISSN: 0008-5472, eISSN: 1538-7445)
Title: Cancer research
Title(ISO): Cancer Res
Publisher: American Association for Cancer Research
 (NLM Catalog  (Scopus  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 72 [継承]
(必須): 22 [継承]
(必須): 5867 5877 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 11月 15日 (平成 24年 11月 15日) [継承]
URL (任意):
DOI (任意): 10.1158/0008-5472.CAN-12-1645    (→Scopusで検索) [継承]
PMID (任意): 23019224    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000311141300023 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1158/0008-5472.CAN-12-1645  (日)    [継承]
2.(英) Article.Affiliation: Division of Genome Medicine, Institute for Genome Research, The University of Tokushima, Tokushima, Tokyo, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tomoya Fukawa, Masaya Ono, Taisuke Matsuo, Hisanori Uehara, Tsuneharu Miki, Yusuke Nakamura, Hiro-omi Kanayama and Toyomasa Katagiri : DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas, Cancer Research, Vol.72, No.22, 5867-5877, 2012.
欧文冊子 ● Tomoya Fukawa, Masaya Ono, Taisuke Matsuo, Hisanori Uehara, Tsuneharu Miki, Yusuke Nakamura, Hiro-omi Kanayama and Toyomasa Katagiri : DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas, Cancer Research, Vol.72, No.22, 5867-5877, 2012.

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