『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=269284)

EID=269284EID:269284, Map:0, LastModified:2014年8月22日(金) 09:12:36, Operator:[勢井 宏義], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ogawa T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Konishi H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Shishioh-Ikejima N (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kiyama H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) The absence of somatotroph proliferation during continuous stress is a result of the lack of extracellular signal-regulated kinase 1/2 activation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The integrity of homeostasis can be affected by chronic stress, and hyposomatotropism is evident in chronic stress-associated illnesses. In the present study, we demonstrated that a continuous stress (CS) severely affected somatotrophs among hormone-secreting cells in the anterior lobe (AL) of the pituitary by using a rat CS model. Among AL cells, the proliferation of somatotrophs was almost entirely suppressed in rats that had 3-5 days of CS (5dCS), although other hormone-secreting cells continued to proliferate. The cell size of somatotrophs was reduced at 5dCS (P<0.01), the number of secretory granules was increased at 3dCS (P<0.01) and serum growth hormone (GH) was on declining trend during 1 to 5dCS, suggesting that GH release was inhibited. GH-releasing hormone (GHRH) mRNA level in the arcuate nucleus was transiently decreased, whereas its receptor expression in the AL was significantly increased in CS rats. When 5dCS rats were injected with GHRH, transient GH secretion was observed, whereas proliferation of somatotrophs did not occur. The GHRH administration failed to stimulate extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and the nuclear translocation of ERK in somatotrophs. These results suggest that somatotrophs of 5dCS rats expressed sufficient GHRH receptor, which could transfer a signal for GH release. However, the GHRH-induced proliferation signal was blocked somewhere between the receptor and ERK1/2. Because significant increase of corticosterone in the initial stage (the 1-3dCS) was observed in this model, the corticosterone may affect the signalling. Although the mechanism underlying the blockage of the proliferation signal in somatotrophs under CS remains unclear, these somatotrophic disorder, suggesting that the present animal model may be useful for understanding the molecular mechanisms of chronic stress-associated illnesses.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Cell Proliferation (日) (読) [継承]
4. (英) Chronic Disease (日) (読) [継承]
5. (英) Corticosterone (日) (読) [継承]
6. (英) Enzyme Activation (日) (読) [継承]
7. (英) Growth Hormone (日) (読) [継承]
8. (英) Growth Hormone-Releasing Hormone (日) (読) [継承]
9. (英) Immunohistochemistry (日) (読) [継承]
10. (英) In Situ Hybridization (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Mitogen-Activated Protein Kinase 1 (日) (読) [継承]
13. (英) Mitogen-Activated Protein Kinase 3 (日) (読) [継承]
14. (英) Phosphorylation (日) (読) [継承]
15. (英) Pituitary Gland, Anterior (日) (読) [継承]
16. (英) Protein Transport (日) (読) [継承]
17. (英) Radioimmunoassay (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Rats, Sprague-Dawley (日) (読) [継承]
20. (英) Real-Time Polymerase Chain Reaction (日) (読) [継承]
21. (英) Somatotrophs (日) (読) [継承]
22. (英) Stress, Psychological (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Neuroendocrinology (British Society for Neuroendrocrinology)
(pISSN: 0953-8194, eISSN: 1365-2826)

ISSN (任意): 1365-2826
ISSN: 0953-8194 (pISSN: 0953-8194, eISSN: 1365-2826)
Title: Journal of neuroendocrinology
Title(ISO): J. Neuroendocrinol.
Supplier: British Society for Neuroendocrinology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 24 [継承]
(必須): 10 [継承]
(必須): 1335 1345 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 10月 初日 (平成 24年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2826.2012.02338.x    (→Scopusで検索) [継承]
PMID (任意): 22612533    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Anatomy & Neurobiology, Graduate School of Medicine, Osaka City University, Abeno-ku, Osaka, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T Ogawa, Hiroyoshi Sei, H Konishi, N Shishioh-Ikejima and H Kiyama : The absence of somatotroph proliferation during continuous stress is a result of the lack of extracellular signal-regulated kinase 1/2 activation., Journal of Neuroendocrinology, Vol.24, No.10, 1335-1345, 2012.
欧文冊子 ● T Ogawa, Hiroyoshi Sei, H Konishi, N Shishioh-Ikejima and H Kiyama : The absence of somatotroph proliferation during continuous stress is a result of the lack of extracellular signal-regulated kinase 1/2 activation., Journal of Neuroendocrinology, Vol.24, No.10, 1335-1345, 2012.

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