『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=269147)

EID=269147EID:269147, Map:0, LastModified:2023年1月27日(金) 14:33:45, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
○種別 (必須):
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Ohnishi Koji (日) (読)
○役割 (任意):
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○学籍番号 (推奨):
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2. (英) Komohara Yoshihiro (日) (読)
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3.坂下 直実
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4. (英) Iyama Ken-Ichi (日) (読)
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5. (英) Murayama Toshihiko (日) (読)
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6. (英) Takeya Motohiro (日) (読)
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○題名 (必須): □(英) Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Although numerous macrophages are found in the lesions of Langerhans cell histiocytosis (LCH), their activation phenotypes and their roles in the disease process have not been clarified. Paraffin-embedded LCH samples were examined on immunohistochemistry and it was found that CD163 can be used to distinguish infiltrated macrophages from neoplastic Langerhans cells (LC). The number of CD163-positve macrophages was positively correlated with the number of multinucleated giant cells (MGC), indicating that most MGC are derived from infiltrated macrophages. A significant number of CD163-positive macrophages were positive for interleukin (IL)-10 and phospho-signal transducer and activator of transcription-3 (pSTAT3), an IL-10-induced signal transduction molecule. This indicates that these macrophages are polarized to anti-inflammatory macrophages of M2 phenotype. Tumor-derived macrophage-colony-stimulating factor (M-CSF) was considered to responsible for inducing M2 differentiation of infiltrated macrophages. The number of CD163-positive macrophages in different cases of LCH varied, and interestingly the density of CD163-positive macrophages was inversely correlated with the Ki-67-positivity of LC. Although the underlying mechanism is not fully elucidated, macrophage-derived IL-10 was considered to be involved in the suppression of tumor cell proliferation via activation of STAT3.  (日)    [継承]
○キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Antigens, CD (日) (読) [継承]
3. (英) Antigens, Differentiation, Myelomonocytic (日) (読) [継承]
4.細胞分化 (cell differentiation) [継承]
5.子ども (children) [継承]
6. (英) Child, Preschool (日) (読) [継承]
7.女性 (female) [継承]
8. (英) Giant Cells (日) (読) [継承]
9. (英) Histiocytosis, Langerhans-Cell (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12.小児 (infant) [継承]
13. (英) Interleukin-10 (日) (読) [継承]
14. (英) Macrophages (日) (読) [継承]
15.男性 (male) [継承]
16. (英) Middle Aged (日) (読) [継承]
17. (英) Phenotype (日) (読) [継承]
18. (英) Receptors, Cell Surface (日) (読) [継承]
19. (英) STAT3 Transcription Factor (日) (読) [継承]
20.シグナル伝達 (signal transduction) [継承]
21. (英) Static Electricity (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Pathology International ([社団法人 日本病理学会])
(pISSN: 1320-5463, eISSN: 1440-1827)

○ISSN (任意): □1440-1827
ISSN: 1320-5463 (pISSN: 1320-5463, eISSN: 1440-1827)
Title: Pathology international
Title(ISO): Pathol Int
Supplier: Japanese Society of Pathology
Publisher: Blackwell
 (NLM Catalog)   (医中誌Web)   (Wiley)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □60 [継承]
○号 (必須): □1 [継承]
○頁 (必須): □27 34 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2010年 1月 初日 (平成 22年 1月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1111/j.1440-1827.2009.02472.x    (→Scopusで検索) [継承]
○PMID (任意): □20055949    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.ELocationID: 10.1111/j.1440-1827.2009.02472.x  (日)    [継承]
2.(英) Article.Affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Koji Ohnishi, Yoshihiro Komohara, Naomi Sakashita, Ken-Ichi Iyama, Toshihiko Murayama and Motohiro Takeya : Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes., Pathology International, Vol.60, No.1, 27-34, (発行所), (都市), Jan. 2010.
欧文冊子 ● (種別) : Koji Ohnishi, Yoshihiro Komohara, Naomi Sakashita, Ken-Ichi Iyama, Toshihiko Murayama and Motohiro Takeya : Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes., Pathology International, Vol.60, No.1, 27-34, (発行所), (都市), Jan. 2010.

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